Korean J Nephrol.  2011 Jan;30(1):80-83.

A Case of Renal Salt Wasting Syndrome Induced by Cisplatin for Chemotherapy

• Hwang HW
• Song SH
• Han ST
• Kim JS
• Han BG
• Choi SO
• Yang JW

Abstract

Cisplatin is widely used for chemotherapy, but known to cause renal, auditory, hematologic, gastrointestinal, and neurologic toxicities. Hyponatremia after administration of cisplatin is related to renal tubular sodium excretion. A 71-year-old female was referred to our hospital for chemotherapy of laryngeal cancer. On admission, the patient's laboratory data were normal. The patient received for 3 days chemotherapy without complication, but presented mental confusion on the 4th hospital day. The laboratory findings were as follows; serum sodium was 118 mmol/L, urine sodium 163 mmol/L, serum osmolality 248 mmol/kg, and urine osmolality 594 mmol/kg. On physical exam, volume status was hypovolemic, so we supplied hypertonic and isotonic salines. On the 9th hospital day, she showed normal sodium concentration and clear consciousness. After chemotherapy, we should make differential diagnosis between SIADH (syndrome of inappropriate antidiuretic hormone) and renal salt wasting syndrome according to the physical examination. We report a case of renal salt wasting syndrome with severe mental change after chemotherapy using cisplatin.

Keyword

Hyponatremia; Cisplatin; Chemotherapy

MeSH Terms

Aged
Cisplatin
Consciousness
Diagnosis, Differential
Female
Humans
Hyponatremia
Hypovolemia
Inappropriate ADH Syndrome
Laryngeal Neoplasms
Osmolar Concentration
Physical Examination
Sodium
Wasting Syndrome
Cisplatin
Sodium