- GBA inhibition suppresses ovarian cancer growth, survival and receptor tyrosine kinase AXL-mediated signaling pathways
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Wang G, Ouyang B, Jing F, Xiaoyan X
- KMID: 2537500
- Korean J Physiol Pharmacol.
- 2023 Jan;27(1):21-29.
- doi: 10.4196/kjpp.2023.27.1.21
The poor outcome of advanced ovarian cancer under conventional therapy necessitates new strategies to improve therapeutic efficacy. β-glucosidase (encoded by GBA) is a lysosomal enzyme and is involved in sphingolipids... -
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- SP1-induced lncRNA MCF2L-AS1 promotes cisplatin resistance in ovarian cancer by regulating IGF2BP1/IGF2/MEK/ERK axis
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Zhu Y, Yang L, Wang J, Li Y, Chen Y
- KMID: 2537966
- J Gynecol Oncol.
- 2022 Nov;33(6):e75.
- doi: 10.3802/jgo.2022.33.e75
Objective Cisplatin resistance is a huge problem encountered in ovarian cancer treatment. Our study probed the roles and the underlying mechanisms of lncRNA MCF2L-AS1 in ovarian cancer cisplatin-resistance. Methods SKOV3 and IGROV-1 cells... -
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- Cisplatin-Induced Ototoxicity: Updates on Potential Molecular Mechanism
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Jung DJ
- KMID: 2534445
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2022 Oct;65(10):569-579.
- doi: 10.3342/kjorl-hns.2022.00507
Cis-diamminedichloroplatinum(II) (cisplatin), platinum compound, is an anti-cancer agent currently used for the treatment of a number of human solid cancers. It irreversibly reacts with DNA to form an interconnection between... -
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- Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
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Park SJ, Lee EJ, Seol A, Park S, Ham J, Yim GW, Shim SH, Lim W, Chang SJ, Song G, Park JW, Kim HS, on behalf of the Korean Rotational Intraperitoneal pressurized Aerosol chemotherapy (KoRIA) Trial Group
- KMID: 2537904
- J Gynecol Oncol.
- 2022 Sep;33(5):e56.
- doi: 10.3802/jgo.2022.33.e56
Objective We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) and evaluated the pharmacokinetics, tissue concentrations, and... -
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- Real-World Outcomes of Gemcitabine, Cisplatin, and Nab-Paclitaxel Chemotherapy Regimen for Advanced Biliary Tract Cancer: A Propensity Score-Matched Analysis
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Jung K, Park J, Jung JH, Lee JC, Kim J, Hwang JH
- KMID: 2533188
- Gut Liver.
- 2022 Sep;16(5):798-805.
- doi: 10.5009/gnl210346
Background/Aims: Advanced biliary tract cancer (BTC) is associated with poor survival. A recent phase II study of triplet combination chemotherapy, including gemcitabine, cisplatin, and nanoparticle albumin-bound (nab)-paclitaxel, has shown promising... -
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- A Single-Arm, Prospective, Phase II Study of Cisplatin Plus Weekly Docetaxel as First-Line Therapy in Patients with Metastatic or Recurrent Salivary Gland Cancer
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Kim HR, Lee SJ, Park S, Jung HA, Lee SH, Jeong HS, Chung MK, Ahn MJ
- KMID: 2531318
- Cancer Res Treat.
- 2022 Jul;54(3):719-727.
- doi: 10.4143/crt.2021.1019
Purpose Salivary gland cancers (SGCs) are relatively rare but comprise various histologic subtypes, which complicates design of prospective trials. Systemic chemotherapy plays a limited role in treatment of SGCs, but... -
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- Nurses’ and Medical Doctors’ Perception and Management Status on Ototoxicity Related to Chemotherapy
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Yu JH, Kim S, Kang MH
- KMID: 2530948
- Asian Oncol Nurs.
- 2022 Jun;22(2):111-120.
- doi: 10.5388/aon.2022.22.2.111
Purpose: The purpose of this study was to investigate the perception of ototoxicity related to chemotherapy (cisplatin) and management status among nurses and doctors. Methods: The participating subjects were 247... -
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- Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin
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Cho H, Choi JH, Kang SY, Lee HW, Choi YW, Kim TH, Ahn MS, Kim CH, Shin YS, Jang JY, Oh YT, Heo J, Sheen SS
- KMID: 2529662
- Korean J Intern Med.
- 2022 May;37(3):653-659.
- doi: 10.3904/kjim.2021.309
Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE... -
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- Comparison of cisplatin-induced anti-tumor response in CT26 syngeneic tumors of three BALB/c substrains
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Gong JE, Jin YJ, Kim JE, Choi YJ, Lee SJ, Kim KS, Jung YS, Cho JY, Lim Y, Kang HG, Hwang DY
- KMID: 2523775
- Lab Anim Res.
- 2021 Dec;37(4):307-319.
- doi: 10.1186/s42826-021-00110-3
Background: To determine whether the background of BALB/c substrains affects the response to anti-tumor drugs, we measured for alterations in tumor growth, histopathological structure of the tumor, and expressions of... -
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- Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle
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Bae JH, Seo DY, Lee SH, Shin C, Jamrasi P, Han J, Song W
- KMID: 2521484
- Korean J Physiol Pharmacol.
- 2021 Nov;25(6):585-592.
- doi: 10.4196/kjpp.2021.25.6.585
Cisplatin has been reported to cause side effects such as muscle wasting in humans and rodents. The physiological mechanisms involved in preventing muscle wasting, such as the regulation of AKT,... -
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- Phase II Trial of Postoperative Adjuvant Gemcitabine and Cisplatin Chemotherapy Followed by Chemoradiotherapy with Gemcitabine in Patients with Resected Pancreatic Cancer
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Lee KH, Chie EK, Im SA, Kim JH, Kwon J, Han SW, Oh DY, Jang JY, Kim JS, Kim TY, Bang YJ, Kim SW, Ha SW
- KMID: 2521584
- Cancer Res Treat.
- 2021 Oct;53(4):1096-1103.
- doi: 10.4143/crt.2020.928
Purpose Despite curative resection, the 5-year survival for patients with resectable pancreatic cancer is less than 20%. Recurrence occurs both locally and at distant sites and effective multimodality adjuvant treatment... -
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- Synergistic Effects of Cisplatin-epigel and Interstitial KTP Laser Treatment on a Xenografted Squamous Cell Carcinoma
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Song MS, Lee SJ, Chung PS, Woo SH
- KMID: 2533525
- Med Lasers.
- 2021 Sep;10(3):170-175.
- doi: 10.25289/ML.2021.10.3.170
Background and Objectives Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the... -
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- Downregulation of LINC01508 contributes to cisplatin resistance in ovarian cancer via the regulation of the Hippo-YAP pathway
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Xiao L, Shi XY, Li ZL, Li M, Zhang MM, Yan SJ, Wei ZL
- KMID: 2526147
- J Gynecol Oncol.
- 2021 Sep;32(5):e77.
- doi: 10.3802/jgo.2021.32.e77
Background Some long non-coding RNAs (lncRNAs) have been found to contribute to cisplatin resistance. Here, we identified a novel lncRNA that was downregulated in cisplatin-resistant to ovarian cancer (OC) cells and... -
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- Clinical Characteristics, Treatment Delivery, and Cisplatin Eligibility in Korean Patients Initially Diagnosed with Urothelial Carcinoma
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Park K, Nam JK, Koo BJ, Lee HJ, Kim TU, Ryu H, Hong YJ, Lee S, Lee DH, Park SW
- KMID: 2518768
- Ewha Med J.
- 2021 Jul;44(3):63-69.
- doi: 10.12771/emj.2021.44.3.63
Objectives: The aim of this study was to examine the clinical presentation, treatment delivery, and cisplatin eligibility of Korean patients with urothelial carcinoma (UC) in a real-world setting. Methods: We performed... -
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- Autologous cervical tumor lysate pulsed dendritic cell stimulation followed by cisplatin treatment abrogates FOXP3+ cells in vitro
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Dhandapani H, Seetharaman A, Jayakumar H, Ganeshrajah S, Singh SS, Thangarajan R, Ramanathan P
- KMID: 2526121
- J Gynecol Oncol.
- 2021 Jul;32(4):e59.
- doi: 10.3802/jgo.2021.32.e59
Objective Dendritic cells (DCs) are administered as immunotherapeutic adjuvants after the completion of standard treatment in most settings. However, our Phase I trial indicated that one patient out of four, who... -
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- Prostaglandin D2 contributes to cisplatin-induced neuropathic pain in rats via DP2 receptor in the spinal cord
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Li Y, Kim WM, Kim SH, You HE, Kang DH, Lee HG, Choi JI, Yoon MH
- KMID: 2510309
- Korean J Pain.
- 2021 Jan;34(1):27-34.
- doi: 10.3344/kjp.2021.34.1.27
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed... -
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- Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
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Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
- KMID: 2509771
- Korean J Intern Med.
- 2021 Jan;36(1):175-181.
- doi: 10.3904/kjim.2019.104
Background/Aims Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect... -
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- Maintenance chemotherapy after 6 cycles of platinum-doublet regimen in anthracycline-and taxane-pretreated metastatic breast cancer
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Joung EK, Yang JH, Oh S, Park SJ, Lee J
- KMID: 2509774
- Korean J Intern Med.
- 2021 Jan;36(1):182-193.
- doi: 10.3904/kjim.2019.129
Background/Aims Sequential monotherapy is recommended for anthracycline-and taxane-resistant metastatic breast cancer (MBC), but combination chemotherapy is considered in patients with visceral crisis. Cisplatin-doublet chemotherapy is a combination regimen for MBC, but... -
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- Cisplatin-induced Atrioventricular Block Requiring a Pacemaker: Two Case Reports and a Literature Review
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Bang HJ, Lee HY, Kim HJ, Yoon N, Chung IJ, Bae WK
- KMID: 2511876
- Electrolyte Blood Press.
- 2020 Dec;18(2):49-52.
- doi: 10.5049/EBP.2020.18.2.49
Chemotherapeutic drugs can cause cardiac toxicities such as cardiomyopathy, arrhythmia, and cardiovascular disease. The well-known side effects of cisplatin are nephrotoxicity, nausea, vomiting, and electrolyte imbalance. Cardiotoxicity induced by cisplatin... -
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- Antinociceptive role of neurotensin receptor 1 in rats with chemotherapy-induced peripheral neuropathy
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Yin M, Kim YO, Choi JI, Jeong S, Yang SH, Bae HB, Yoon MH
- KMID: 2507137
- Korean J Pain.
- 2020 Oct;33(4):318-325.
- doi: 10.3344/kjp.2020.33.4.318
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of anti-cancer drugs. Neurotensin receptors (NTSRs) are widely distributed within the pain circuits in the central nervous system. The purpose... -
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