Korean J Biol Psychiatry.  2006 Nov;13(4):299-304.

Association Study between Tic Disorder and Dopamine D2 Receptor Gene Polymorphism in Korean Population

• Lee SI
• Cho IH
• Kim SM
• Lee MS
• Jung HY

Abstract

OBJECTIVES
The purpose of the present study was to investigate whether the Taq I A polymorphism of dopamine receptor D2 gene(DRD2) is associated with Tourette syndrome(TS) and chronic motor tic disorder(CMT) in Korean population.
METHODS
DRD2 Taq I A RFLP genotyping was carried out with DNA extracted from blood samples of 75 patients with tic disorders(47 with TS and 28 with CMT) and 90 healthy subjects. Genotype and allelic frequencies for the DRD2 gene polymorphisms of the tic disorder group as a whole were compared to those of the control group. Separating the TS group, thereafter, the frequency of genotypes and alleles were compared to those of the controls.
RESULTS
The results demonstrated that genotype and allele distributions for the DRD2 gene polymorphism in the tic disorder as a whole, TS, and control groups were not significantly different.
CONCLUSION
No association was found for DRD2 gene, TS and CMT. The data suggest that DRD2 gene may not be a useful marker for the prediction of the susceptibility of tic disorder.

Keyword

Tourette syndrome; Chronic motor tic disorder; Gene polymorphism; Receptors, dopamine D2; Taq I RFLP

MeSH Terms

Alleles
DNA
Dopamine*
Genotype
Humans
Polymorphism, Restriction Fragment Length
Receptors, Dopamine
Receptors, Dopamine D2*
Tic Disorders*
Tics*
Tourette Syndrome
DNA
Dopamine
Receptors, Dopamine
Receptors, Dopamine D2