J Korean Neuropsychiatr Assoc.
1999 Nov;38(6):1488-1493.
No Association between DRD2 polymorphism Ser311/Cys311 and Bipolar Disorder in Korean Population
- Affiliations
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- 1Hur's Neuropsychiatric Clinic, Cheon-Ahn, Chungnam, Korea.
- 2Department of Psychiatry, College of Medicine, Chungnam National University, Taejon, Korea.
- 3Department of Anatomy, College of Medicine, Chungnam National University, Taejon, Korea.
Abstract
OBJECTIVES
This study was designed to investigate the association between Ser311/Cys311 polymorphism in the dopamine D2 receptor gene and bipolar disorder in korean population. METHOD: Ser311/Cys311 polymorphism in the dopamine D2 receptor gene was typed with PCR in 86 bipolar disorders and 100 normal controls.
RESULTS
Genotype of Ser/Ser, Ser/Cys, Cys/Cys were 82 (95.3%), 4 (4.7%), 0 (0.0%) respectively in the bipolar disorders, 96 (96.0%), 4 (4.0%), 0 (0.0%) respectively in the controls. Allele frequencies of Ser and Cys were 168 (97.7%), 4 (2.3%) in the bipolar disorders, 196 (98.0%), 4 (2.0%) in the controls. There were no differencies in genotype distribution and allele frequencies of dopamine D2 receptor gene polymorphism Ser311/Cys311 between in the bipolar disorders and in the controls.
CONCLUSION
These result suggests dopamine D2 receptor gene polymorphism Ser311/Cys311 is not causally related to the development of bipolar disorder in korean population.
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