Korean J Anesthesiol.  1998 Aug;35(2):360-364. 10.4097/kjae.1998.35.2.360.

General Anesthesia for the Management of Status Epilepticus Refractory to Conventional Drugs: A case report

• Kim JS
• Kim YS
• Cho SD
• Song NW

• KMID: 2298955
• DOI: http://doi.org/10.4097/kjae.1998.35.2.360

Abstract

A 2.5-year-old female patient who has a prior history of partial seizures was admitted by generalized tonic-clonic status epilepticus secondary to tapering of phenobarbital. Tonic-clonic status epilepticus was refractory to phenytoin, phenobarbital, valproic acid, diazepam, and pentobarbital. After 4 days of unsatisfactory control of seizure activity, isoflurane was administered for 4 hours. Inspired isoflurane concentration of 1.3% were required to control seizures. Heart rate and blood pressure were supported with infusions of dopamine and fluid. After discontinuation of isoflurane, the patient developed partial seizures but seizure activity was controlled with anticonvulsants. She was discharged alive from the hospital after weaning of the ventilator.

Keyword

Anesthetics, volatile: isoflurane; Anticonvulsants: phenobarbital; phenytoin; Seizure: status epilepticus

MeSH Terms

Anesthesia, General*
Anticonvulsants
Blood Pressure
Diazepam
Dopamine
Female
Heart Rate
Humans
Isoflurane
Pentobarbital
Phenobarbital
Phenytoin
Seizures
Status Epilepticus*
Valproic Acid
Ventilators, Mechanical
Weaning
Anticonvulsants
Diazepam
Dopamine
Isoflurane
Pentobarbital
Phenobarbital
Phenytoin
Valproic Acid