J Asthma Allergy Clin Immunol.  2002 Jun;22(2):475-480.

A case of Churg-Strauss syndrome associated with zafirlukast

• Oh JW
• Kim NJ
• Cho YD
• Lee HS
• Lee KC
• Nam SY
• Kim HS
• Jeong JW
• Kim WK

Abstract

Churg-Strauss syndrome (CSS) is an eosinophil associated disease, characterized by vaculitis and granulomatosis on small vessel, asthma and eosinophil tissue infiltration. Several cases of CSS have been reported in patients treated with cysteinyl leukotriene receptor antagonist and weaned-off systemic or inhaled corticosteroids. A 39-year-old man with a history of childhood allergic rhinitis was diagnosed with bronchial asthma and his symptoms were well controlled with fluticasone propinate, salmeterol and zafirlukast. However four months later, he was admitted again with prominent skin lesions, tingling sensation on both extremities and fever. We diagnosed CSS with a history of sinusitis and bronchial asthma, marked peripheral eosinophilia, vasculitis and neuropathy. His symptoms and laboratory findings promptly improved after ten days of intravenous corticosteroid and cessation of zafirlukast without recurrence for six months during the follow-up period. We conclude that zafirlukast may cause CSS and attention should be taken when using zafirlukast.

Keyword

Churg-strauss syndrome; Zafirlukast

MeSH Terms

Adrenal Cortex Hormones
Adult
Asthma
Churg-Strauss Syndrome*
Eosinophilia
Eosinophils
Extremities
Fever
Follow-Up Studies
Fluticasone
Humans
Receptors, Leukotriene
Recurrence
Rhinitis
Salmeterol Xinafoate
Sensation
Sinusitis
Skin
Vasculitis
Adrenal Cortex Hormones
Receptors, Leukotriene