Korean J Physiol Pharmacol.
1999 Jun;3(3):315-320.
Tissue-specific regulation of angiotensinogen and angiotensin II receptor gene expression in deoxycorticosterone acetate-salt hypertensive rats
- Affiliations
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- 1Department of Physiology, Chonnam University Medical School, 5 Hak-dong, Kwangju, 501-190 South Korea.
- 2Department of Veterinary Medicine, Chonnam University College of University Medicine, Kwangju 500-757 South Korea.
Abstract
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Molecular regulation of the renin-angiotensin system (RAS) was
investigated in deoxycorticosterone acetate (DOCA)-salt hypertension.
The expression of renin, angiotensinogen and angiotensin II receptor
genes in the kidney and liver was determined by Northern blot analysis
in rats which were made DOCA-salt hypertensive over the period of 2 or
4 weeks. Along with the hypertension, renin mRNA was decreased in the
remnant kidney. The expression of angiotensinogen gene was not
significantly altered in the kidney, but was significantly decreased in
the liver. The expression of angiotensin II receptor gene was increased
in the kidney, while it remained unaltered in the liver. The duration
of hypertension did not affect the altered gene expression. It is
suggested that the components of RAS are transcriptionally regulated in
DOCA-salt hypertension in a tissue-specific manner.