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Replication of Recombinant Flock House Virus RNA Encapsidated by Turnip Yellow Mosaic Virus Coat Proteins in Nicotiana benthamiana

Kim D, Cho TJ

It was previously observed that recombinant flock house virus (FHV) RNA1 was efficiently packaged into turnip yellow mosaic virus (TYMV), provided that the TYMV coat protein (CP) sequence was present...
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Viral Effects of a dsRNA Mycovirus (PoV-ASI2792) on the Vegetative Growth of the Edible Mushroom Pleurotus ostreatus

Song HY, Choi HJ, Jeong H, Choi D, Kim DH, Kim JM

A double-stranded RNA (dsRNA) mycovirus was detected in malformed fruiting bodies of Pleurotus ostreatus strain ASI2792, one of bottle cultivated commercial strains of the edible oyster mushroom. The partial RNA-dependent...
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Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells

Hwang YS, Lindholm P

BACKGROUND: Tumor growth and invasion are interconnected with the tumor microenvironment. Overexpression of genes that regulate cancer cell invasion by growth factors, cytokines, and lipid factors can affect cancer aggressiveness....
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TGF-beta Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells

Kang S, Min A, Im SA, Song SH, Kim SG, Kim HA, Kim HJ, Oh DY, Jong HS, Kim TY, Bang YJ

PURPOSE: Overexpression of cyclooxygenase 2 (COX-2) is thought to promote survival of transformed cells. Transforming growth factor beta (TGF-beta) exerts anti-proliferative effects on a broad range of epithelial cells. In...
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Genome Size Constraint in Replication and Packaging of Turnip Yellow Mosaic Virus

Kim HB, Chae KH, Cho TJ

Turnip yellow mosaic virus (TYMV) is a spherical plant virus that has a single 6.3 kb positive strand RNA as a genome. Previously, we have made the recombinant TYMV construct...
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Expression of the S glycoprotein of transmissible gastroenteritis virus (TGEV) in transgenic potato and its immunogenicity in mice

Ahn DJ, Youm JW, Kim SW, Yoon WK, Kim HC, Hur TY, Joung YH, Jeon JH, Kim HS

  • KMID: 1790568
  • Korean J Vet Res.
  • 2013 Dec;53(4):217-224.
Transgenic plants have been tested as an alternative host for the production and delivery of experimental oral vaccines. Here, we developed transgenic potatoes that express the major antigenic sites A...
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Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells

Jeon YJ, Kim YS

BACKGROUND/AIMS: Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. METHODS: Huh7 cells were...
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Expression of peroxiredoxin I regulated by gonadotropins in the rat ovary

Lee YI, Kang WD, Kim MY, Cho MK, Chun SY

OBJECTIVE: Peroxiredoxins (Prxs) play an important role in regulating cellular differentiation and proliferation in several types of mammalian cells. This report examined the expression of Prx isotype I in the...
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Ethanol down regulates the expression of myelin proteolipid protein in the rat hippocampus

Lee DH, Jeong JY, Kim YS, Kim JS, Cho YW, Roh GS, Kim HJ, Kang SS, Cho GJ, Choi WS

It is well known that chronic ethanol treatment affects the synthesis of RNA and protein in the brain and the maintenance and function of nervous system. The changes in myelination-related...
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Functional Characterization of cAMP-Regulated Gene, CAR1, in Cryptococcus neoformans

Jung KW, Maeng S, Bahn YS

  • KMID: 2312560
  • Mycobiology.
  • 2010 Mar;38(1):26-32.
The cyclic AMP (cAMP) pathway plays a major role in growth, sexual differentiation, and virulence factor synthesis of pathogenic fungi. In Cryptococcus neoformans, perturbation of the cAMP pathway, such as...
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Suppressed Gastric Mucosal TGF-beta1 Increases Susceptibility to H. pylori-Induced Gastric Inflammation and Ulceration: A Stupid Host Defense Response

Jo Y, Han SU, Kim YJ, Kim JH, Kim ST, Kim SJ, Hahm KB

  • KMID: 2167205
  • Gut Liver.
  • 2010 Mar;4(1):43-53.
BACKGROUND/AIMS: Loss of transforming growth factor beta1 (TGF-beta1) exhibits a similar pathology to that seen in a subset of individuals infected with Helicobacter pylori, including propagated gastric inflammation, oxidative stress,...
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The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells

Jang YY, Kim NK, Kim MK, Lee HY, Kim SJ, Kim HS, Seo HY, Lee IK, Park KG

BACKGROUND: The highly developed endoplasmic reticulum (ER) structure in pancreatic beta cells is heavily involved in insulin biosynthesis. Thus, any perturbation in ER function inevitably impacts insulin biosynthesis. Recent studies...
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Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells

Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK

Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the...
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Isolation of Genes Specifically Expressed in Different Developmental Stages of Pleurotus ostreatus Using Macroarray Analysis

Lee SH, Joh JH, Lee JS, Lim JH, Kim KY, Yoo YB, Lee CS, Kim BG

The oyster mushroom (Pleurotus ostreatus) is one of the most important edible mushrooms worldwide. The mechanism of P. ostreatus fruiting body development has been of interest both for the basic...
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Characterization of a Novel Gene in the Extended MHC Region of Mouse, NG29/Cd320, a Homolog of the Human CD320

Park HJ, Kim JY, Jung KI, Kim TJ

BACKGROUND: The MHC region of the chromosome contains a lot of genes involved in immune responses. Here we have investigated the mouse NG29/Cd320 gene in the centrometrically extended MHC region...
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MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer

Son JW, Kim YJ, Cho HM, Lee SY, Jang JS, Choi JE, Lee JU, Kang MG, Lee YM, Kwon SJ, Choi E, Na MJ, Park JY

  • KMID: 2319278
  • Tuberc Respir Dis.
  • 2009 Nov;67(5):413-421.
BACKGROUND: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer...
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Native low-density lipoprotein-induced superoxide anion contributes to proliferation of human aortic smooth muscle cells

Lim HK, Shin W, Lee JY, Ryoo S

BACKGROUND: Native low-density lipoprotein (nLDL) was one of the modifiable risk factors contributed directly to cardiovascular diseases development. We investigated that nLDL stimulation induced NADPH oxidase activation and superoxide production...
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The effect of five osteotropic factors on osteoprotegerin mRNA expression in gingival fibroblasts

Ko YK

PURPOSE: Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor (TNF) receptor family that inhibits bone resorption by suppressing osteoclastogenesis. Gingival fibroblasts (GF) play a...
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Gonadotropin Regulation of Regulator of G Protein Signaling 2 (RGS-2) Expression in the Rat Ovary

Lee YI, Lee ES, Kim SA, Kim MY, Cho MK, Chun SY

  • KMID: 1986919
  • Korean J Reprod Med.
  • 2008 Jun;35(2):111-118.
OBJECTIVE: The purpose of the present study was to examine the hormonal regulation of RGS-2 in the rat ovary. METHODS: Immature rats were injected with 10 IU of PMSG to induce...
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Aquaporin 1 expression in tissues of canines possessing inherited high K+ erythrocytes

Ochiai H, Hishiyama , Hisamatsu , Kanemaki N

We investigated the expression of aquaporin 1 (AQP1) in tissues from canines with an inherited anomaly that causes their erythrocytes to have high K+. Northern blot analysis revealed abundant AQP1...
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