Korean J Physiol Pharmacol.  2001 Jun;5(3):253-258.

Coordinate expression of renin and cyclooxygenase-2 in rats with two-kidney, one clip and deoxycorticosterone acetate-salt hypertension

Affiliations
  • 1Department of Physiology, Chonnam National University Medical School,South Korea. julee@chonnam.ac.kr

Abstract

The present study was aimed to examine whether the expression of renin is associated with that of cyclooxygenase-2 (COX-2) in the kidney. Male Sprague-Dawley rats were made two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertensive, to stimulate or to inhibit the endogenous renin-angiotensin system, respectively. The expression of renin and COX-2 mRNA was determined in the cortex of the kidney by reverse transcription-polymerase chain reaction. 2K1C hypertensive rats showed an increased expression of renin as well as of COX-2 in the clipped kidney. The expression of renin was decreased in parallel with that of COX-2 in the contralateral non-clipped kidney. Removal of the renal arterial clip reversed the expression of both genes, along with the blood pressure, to the control level. On the other hand, DOCA-salt hypertension was associated with parallel decreases of renin and COX-2 expression. These results indicate that renin and COX-2 genes are coordinately expressed in the kidney.


MeSH Terms

Animals
Blood Pressure
Cyclooxygenase 2*
Desoxycorticosterone*
Hand
Humans
Hypertension*
Kidney
Male
Rats*
Rats, Sprague-Dawley
Renin*
Renin-Angiotensin System
RNA, Messenger
Cyclooxygenase 2
Desoxycorticosterone
RNA, Messenger
Renin
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