Korean J Phys Anthropol.  2004 Jun;17(2):109-119.

Localization of Nerves Innervating Sublingual and Submandibular Gland in the CNS Using Cholera Toxin B Subnit and Pseudorabies Virus

  • 1Department of Anatomy and Institute for Medical Science Chonbuk National University Medical School, Korea. han@chonbuk.ac.kr
  • 2Department of Anatomy, College of Oriental Medicine, Woosuk University, Korea.


In the rat brain stem, neurons innervating the sublingual and submandibular gland were investigated by means of cholera toxin B subunit (CTB) and pseudorabies virus (PRV). Injection of CTB into the sublingual gland and PRV into the submandibular gland, neural tracer labeled neurons showed similar positions in central nervous system with PRV into the sublingual gland and CTB into the submandibular gland. CTB labeled-neurons were observed in superior salivatory nucleus, PRV labeled-neurons in superior salivatory nucleus and reticular nucleus. CTB was more fine tracer than PRV for observation of superior salivatory nucleus. The size of CTB labeled-neurons is larger in submandibular gland than in sublingual gland. The size of PRV labeled-neurons were nearly the same after injection to submandibular or sublingual gland. No neurons were labeled together with CTB and PRV. Neurons innervating sublingual and submandibular gland were localized independently in superior salivatory nucleus. These results provided a neuroanatomical data of the neurons innervating the sublingual and submandibular gland in the superior salivatory nucleus.


CTB; PRV; Submandibular gland; Sublingual gland
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