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A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens

Park JY, Park SY, Kwon H, Song Y, Yun B, Lee Y, Cho Y, Joo A, Han PL

The nucleus accumbens (NAc) is the major component of the ventral striatum that regulates stress-induced depression. The NAc receives dopaminergic inputs from the ventral tegmental area (VTA), and the role...
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Epidemiology, management, and prevention of cholera

Bae IG

Cholera is an acute secretory form of diarrhea caused by a potent enterotoxin (cholera toxin) after ingestion of toxigenic Vibrio cholerae of the O1 or O139 serogroups. Although cholera is...
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Antibody Production, Anaphylactic Signs, and T-Cell Responses Induced by Oral Sensitization With Ovalbumin in BALB/c and C3H/HeOuJ Mice

Pablos-Tanarro A, Lopez-Exposito I, Lozano-Ojalvo D, Lopez-Fandino R, Molina E

PURPOSE: Two mouse strains, BALB/c and C3H/HeOuJ, broadly used in the field of food allergy, were compared for the evaluation of the allergenic potential of ovalbumin (OVA). METHODS: Sensitization was made...
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Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion

Cho JA, Park E

BACKGROUND/OBJECTIVES: Curcumin, a major component of the Curcuma species, contains antioxidant and anti-inflammatory properties. Although it was found to induce apoptosis in cancer cells, the functional role of curcumin as...
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Eosinophils are Required for Immune Responses Induced by Oral Immunization

Jung Y

Eosinophils are multifunctional leukocytes that reside in several tissues, most abundantly in the small intestinal lamina propria under the steady state. To date, the phenotypic and functional characteristics of small...
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Effect of Cholera Toxin Administered Supraspinally or Spinally on the Blood Glucose Level in Pain and D-Glucose Fed Animal Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Jung JS, Ryu OH, Choi MG, Choi SS, Suh HW

In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment...
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Caspase-11, the Main Executioner in Non-canonical Inflammasome

Manzoor Z, Koh YS

Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11...
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Immunogenicity and Protective Efficacy of a Dual Subunit Vaccine Against Respiratory Syncytial Virus and Influenza Virus

Park MH, Chang J

Respiratory syncytial virus (RSV) and influenza virus are the most significant pathogens causing respiratory tract diseases. Composite vaccines are useful in reducing the number of vaccination and confer protection against...
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Generation of transgenic corn-derived Actinobacillus pleuropneumoniae ApxIIA fused with the cholera toxin B subunit as a vaccine candidate

Shin MK, Jung MH, Lee WJ, Choi PS, Jang YS, Yoo HS

Corn, one of the most important forage crops worldwide, has proven to be a useful expression vehicle due to the availability of established transformation procedures for this well-studied plant. The...
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The Influences of G Proteins, Ca2+, and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle

Park JH, Kim HS, Park SY, Im C, Jeong JH, Kim IK, Sohn UD

NO released by myenteric neurons controls the off contraction induced by electrical field stimulation (EFS) in distal esophageal smooth muscle, but in the presence of nitric oxide synthase (NOS) inhibitor,...
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Effects of the Human-Mesenchymal Stem Cells Transplantation on Spinal Cord Injury of the Rats

Park YL, Moon JS, Chung YY, Kim J, Song CH, Kim JJ

  • KMID: 2092896
  • Korean J Anat.
  • 2007 Jun;40(2):115-125.
Two sources of adult stem cells that have aroused great interest are human bone marrow-derived mesenchymal stem cells (hMSCs) and human umbilical cord blood cells. hMSCs have been reported to...
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Differentiation of Pancreatic beta Cells from Human Pancreatic Duct Cells Derived from a Partial Pancreas Tissue

Song KH, Kim MM, Lee MK, Ryu GR, Ko SH, Moon SD, Ahn YB, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Chin HM

BACKGROUND: Despite a recent breakthrough in human islet transplantation for treating diabetes mellitus, the limited availability of insulin-producing tissue is still a major obstacle. This has led to a search...
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Transcutaneous DNA immunization of HPV-16 E7 with hair-follicle specific promoter in mice

Kim CJ, Kim TW, Noh KH, Lee KH, Lee HN, Lee YS, Park TC, Namkoong S, Park JS

  • KMID: 1870362
  • Korean J Obstet Gynecol.
  • 2007 Mar;50(3):512-522.
OBJECTIVE: Previous reports have shown that transcutaneous immunization (TCI) with proteins or peptides in combination with adjuvants efficiently induces specific cellular and humoral immune responses. We compared the immune response...
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Evaluation of Anti-allergic Effect of Bifidobacteria in Murine Model of Peanut Allergy

Lee SY, Oh SK, Park SW, Jeon GR, Kim JY, Yoon SY, Ji GE

  • KMID: 2314412
  • Pediatr Allergy Respir Dis.
  • 2006 Jun;16(2):131-141.
PURPOSE: We underwent this study to evaluate the immunomodulating effects of intragastric administration of bifidobacterium(BGN4) using murine model of peanut allergy. METHODS: C3H/HeJ mice were sensitized with 1 mg/dose of crude...
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Changes of Calretinin-Immunoreactivities in the Rat Superior Collicuclus after Eye Enucleation

Yoon SP, Kim HY, Jun YJ, Chang IY

  • KMID: 2283207
  • Korean J Phys Anthropol.
  • 2005 Sep;18(3):179-186.
Calcium-binding proteins play an important role in the protection, differentiation, and reorganization of the central nervous system. The effects of neonatal retinal deafferentiation on calretinin, and tracing of retinotectal pathway...
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Transcutaneous DNA vaccination increase the CTL response: Preliminary results for the therapeutic HPV DNA vaccination

Kim CJ, Yim EK, Lee HN, Lee KH, Park TC, Namkoong S, Park JS

  • KMID: 1575053
  • Korean J Gynecol Oncol.
  • 2005 Sep;16(3):242-255.
OBJECTIVE: Transcutaneous immunization (TCI) is a novel vaccination based on the application onto bare skin. We compared the immune response after TCI with the model DNA (OVALBUMIN) to HPV E7...
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Activation of Vestibular Neurons Projecting to Autonomic Brain Stem Nuclei Following Acute Hypotension in Rats

Choi MA, Wang WK, Choi DO, Kim MS, Park BR

  • KMID: 2285297
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):133-140.
The purpose of the present study was to elucidate the possible involvement of the medial vestibular nucleus (MVN) and inferior vestibular nucleus (IVN) following acute hypotension in the vestibulo- autonomic...
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Localization of Nerves Innervating Sublingual and Submandibular Gland in the CNS Using Cholera Toxin B Subnit and Pseudorabies Virus

Han EH, Song KS, Lee CH

  • KMID: 2283178
  • Korean J Phys Anthropol.
  • 2004 Jun;17(2):109-119.
In the rat brain stem, neurons innervating the sublingual and submandibular gland were investigated by means of cholera toxin B subunit (CTB) and pseudorabies virus (PRV). Injection of CTB into...
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Localization of Motor Neuronal Cell Bodies Innervating the Digastric Muscle of the Rat Using Cholera Toxin B Subunit (CTB)

Kim JH, Han EH

  • KMID: 2224508
  • Korean J Anat.
  • 2004 Jun;37(3):283-292.
We used cholera toxin B subunit (CTB) as a neural tracer to localize motor neuronal cell bodies innervating the digastric muscle. After CTB injection into the left anterior belly, CTB-labelled...
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Induction of Mucosal Tolerance Using House Dust Mite-Cholera Toxin B Conjugate in Mouse Model of Allergic Rhinitis: Prophylactic and Long-Term Therapeutic Effects

Lee CH, Oh SJ, Kang JG, Roh JL, Lee SS, Quan SH, Rhee CS, Min YG, Sung SY

  • KMID: 2276117
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Mar;47(3):232-237.
BACKGROUND AND OBJECTIVES: Cholera toxin B (CTB) is an effective immunomodulating agent. Mucosal tolerance is a well recognized method for inducing tolerance, but large amounts of antigen is needed. The...
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