Korean J Phys Anthropol.
1998 Jun;11(1):155-163.
Immunohistological Study on the Distribution of Type I Collagen of the Skin in Adriamycin Treated Rats
- Affiliations
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- 1Department of Anatomy, College of Medicine, Hanyang University and Institute of Biomedical Sciences, Korea.
- 2Department of Orthopedic Surgery, College of Medicine, KwanDong University, Korea.
Abstract
- The present study was designed to detect the distribution of the type I collagens in the three regions, papillary layer, reticular layer and subcutaneous layer of skin in the rats after administration of adriamycin. Intraperitoneally, 1 injections of 5 mg/kg of adriamycin for every 3 days were given and sacrificed 12 hours, 24 hours, 3 days and 1 week later respectively. For the immunoreactions of type I collagen, the specimens were incubated with rabbit anti rat type I collagen polyclonal antibody as primary antibody and biotinylated Goat anti rabbit IgG antibody as secondary antibody. And ABC peroxidase procedure was used. The reactions of type I collagen in the dermis of adriamycin treated rat skin were decreased from 12 hours to 3 day and from 7 day the immunoreactions are constant as like that of normal rats. Adriamycin seems to be suppressing normal components of type I collagen in rat skin.
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