Diabetes Metab J.  2011 Aug;35(4):404-410. 10.4093/dmj.2011.35.4.404.

Postprandial Triglyceride Is Associated with Fasting Triglyceride and HOMA-IR in Korean Subjects with Type 2 Diabetes

• Lee SH
• Lee BW
• Won HK
• Moon JH
• Kim KJ
• Kang ES
• Cha BS
• Lee HC

• KMID: 2281648
• DOI: http://doi.org/10.4093/dmj.2011.35.4.404

Abstract

BACKGROUND
Recent studies indicate postprandial triglyceride (TG) had a better association with cardiovascular events and metabolic syndrome than fasting TG. The authors of the present study investigated the metabolic and clinical relevance of postprandial TG.
METHODS
In a cross-sectional retrospective study, the authors of the present study compared fasting and postprandial TG and analyzed the relationship between postprandial TG and various demographic and metabolic parameters in 639 Korean subjects with type 2 diabetes (T2D, group I, n=539) and impaired fasting glucose (IFG, group II, n=100) after ingestion of a standardized liquid meal (total 500 kcal, 17.5 g fat, 68.5 g carbohydrate, and 17.5 g protein).
RESULTS
Fasting and postprandial TG were significantly correlated (r=0.973, r=0.937, P<0.001) in group I and II, respectively. Of the variables, total cholesterol, waist circumference and body mass index were significantly correlated with fasting and postprandial TG in both groups. Only postprandial TG showed a significant correlation with glucose metabolic parameters (e.g., postprandial glucose, homeostatic model assessment of insulin resistance [HOMA-IR], and fasting C-peptide) in subjects with T2D. Multiple regression analysis showed fasting TG and HOMA-IR could be predictable variables for postprandial TG in subjects with T2D.
CONCLUSION
Postprandial TG was very strongly correlated with fasting TG. The authors of the present study suggest insulin resistance may be more associated with postprandial TG than fasting TG in Korean T2D patients on a low-fat diet.

Keyword

Diabetes; Diet, fat-restricted; Non-fasting triglyceride; Triglycerides

MeSH Terms

Body Mass Index
Cholesterol
Diet, Fat-Restricted
Eating
Fasting
Glucose
Humans
Insulin Resistance
Meals
Retrospective Studies
Triglycerides
Waist Circumference
Cholesterol
Glucose
Triglycerides

Figure

• 

  Fig. 1 Correlation between plasma fasting triglyceride (TG) levels and postprandial TG levels in subjects with type 2 diabetes (A) and impaired fasting glucose (B).

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