Korean J Perinatol.  2015 Sep;26(3):190-199. 10.14734/kjp.2015.26.3.190.

Neonatal Outcomes of Premature Infants Who Were Delivered from Mother with Hypertensive Disorders of Pregnancy and Effects of Antihypertensive Drugs and MgSO4

• Suh BS
• Ko KH
• Bang JS
• Oh YJ
• Lee YJ
• Lee JW
• Lee KH
• Sung TJ

• KMID: 2281222
• DOI: http://doi.org/10.14734/kjp.2015.26.3.190

Abstract

PURPOSE
Hypertensive disorders of pregnancy increase morbidity and mortality of fetus and neonates. Recently some studies revealed that antihypertensive agents affected the neonatal outcomes. The aim of this study was to investigate the prognosis of preterm infants delivered from the mothers with hypertensive disorders who were treated with antihypertensive agents and magnesium sulfate.
METHODS
This retrospective study was conducted on preterm infants who were delivered from normotensive mother (control, n=436) and antihypertensive drugs +/- magnesium sulfate treated mother (study, n=150) between January 2009 and December 2013. Study group were divided into two groups based on whether they received antihypertensive drugs only (n=110) and additional magnesium sulfate (n=40). We compared the characteristics of mothers and neonatal outcomes.
RESULTS
Study group had shorter gestational age (32.2+/-3.5 weeks vs. 33.7+/-3.0 weeks, P=0.000) and lower birth weight (1,810.5 +/- 689.2 g, 2,212.1 +/- 604.9 g, P=0.000), and higher rate of small for gestational age infants (22% vs 11%, P=0.000). One minute and 5 minutes Apgar score were lower, but duration of hospital days, oxygen supplement and mechanical ventilation were longer in study group. Respiratory distress syndrome, bronchopulmonary dysplasia, patent ductus arteriosus, retinopathy of prematurity, intraventricular hemorrhage occurred more in study group than control. The group treated with magnesium sulfate together with antihypertensive agent had lower 1 minute and 5 minutes Apgar score than the group taken antihypertensive agent only.
CONCLUSIONS
Mothers with hypertensive disorders have increased the risk of preterm delivery, low birth weight, and high neonatal morbidity rate. Therefore it is important to predict and manage possible complication. Moreover, if magnesium sulfate is taken, careful neonatal monitoring is needed because of possible low Apgar score.

Keyword

Antihypertensive agents; Magnesium sulfate; Premature infant

MeSH Terms

Antihypertensive Agents*
Apgar Score
Birth Weight
Bronchopulmonary Dysplasia
Ductus Arteriosus, Patent
Fetus
Gestational Age
Hemorrhage
Humans
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Magnesium Sulfate
Mortality
Mothers*
Oxygen
Pregnancy*
Prognosis
Respiration, Artificial
Retinopathy of Prematurity
Retrospective Studies
Antihypertensive Agents
Magnesium Sulfate
Oxygen

Figure

• 

  Fig. 1. Schematic view of study population. Abbreviation: anti-HT, antihy pertensive drugs.

Reference

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