Clin Pediatr Hematol Oncol.  2014 Oct;21(2):149-152. 10.0000/cpho.2014.21.2.149.

A Pediatric Case of Acute Myeloid Leukemia with t(3;5)(q25;q34)

• Kim BY
• Jeon IS

• KMID: 2279826
• DOI: http://doi.org/10.0000/cpho.2014.21.2.149

Abstract

Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodysplasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children. NPM1/MLF1 fusion gene produced as a result of t(3;5)(q25;q34) was cloned, however, the exact mechanism of its role in leukemogenesis has not been clarified. Although this cytogenetic abnormality is regarded as an intermediate risk factor, its clinical significance is controversial until now. More cases need to be reported and investigated, therefore we present a case of AML with t(3;5)(q25;q34) in a 14-year-old girl with literature review.

Keyword

Acute myeloid leukemia; t(3;5)(q25;q34); NPM; MLF

MeSH Terms

Adolescent
Child
Chromosome Aberrations
Classification
Clone Cells
Female
Humans
Leukemia, Myeloid, Acute*
Risk Factors