Korean J Clin Pathol.  1999 Apr;19(2):266-270.

ider (9) (q10)t (9;22) (q34;q11.2) as Secondary Karyotypic Aberration of Chronic Myelogeous Leukemia

  • 1Department of Clinical Pathology, College of Medicine, Keimyung University, Korea.
  • 2Department of Internal Medicine, College of Medicine, Kyungpook University, Taegu, Korea.
  • 3Department of Clinical Pathology, College of Medicine, Kyungpook University, Taegu, Korea.


Although occasional patients with chronic myeloid leukemia (CML) have chromosomal changes other than Philadelphia chromosome early in the disease, in typical cases the 9;22 translocation remains the sole abnormality throughout the disease course in chronic phase. When disease progression occurs, however, 75-80% develop additional chromosome aberrations. These secondary changes sometimes precede the more aggressive manifestations hematologically and clinically and thus may serve as valuable prognostic indicators. ider (9) (q10)t (9;22) (q34;q11.2) is very rare and a recurrent chromosomal abnormality associated with acute lymphoblastic leukemias (ALL) and lymphoblastic crisis of CML. And ider (9) (q10)t (9;22) (q34;q11.2) is a lymphoid-specific rearrangement and the patients with this abnormality are of older age on average. They commonly show pre-B cell lineage immunophenotype and L2 morphology. We report a case of ider (9) (q10)t (9;22) (q34;q11.2) as secondary aberration in a patient with lymphoblastic crisis of CML.


ider (9) (q10)t (9;22) (q34;q11.2); Blast crisis; Chronic myeloid leukemia

MeSH Terms

Blast Crisis
Chromosome Aberrations
Disease Progression
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cells, B-Lymphoid
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