Korean J Otolaryngol-Head Neck Surg.  2002 Jan;45(1):56-61.

Effects of the Genetic Polymorphisms of CYP1A1 and GSTP1 on the Risk of Laryngeal Cancer in Koreans

• Lee GH
• Shim YS
• Lee YS
• Lee BC
• Seong MS
• Hong YJ
• Kim HJ
• Kim H
• Kim YJ

Abstract

BACKGROUND AND ackground and Objectives: Smoking has been reported as an important risk factor of laryngeal cancer. Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase P1 (GSTP1) are genes that encode enzymes which are involved in the metabolism of carcinogens in cigarette smoke. In this study, we statistically tested the significances of smoking and genotypes of CYP1A1 and GSTP1 as risk factors of laryngeal cancer. MATERIALS AND METHOD: In this case-control study, 84 pathologically proven laryngeal cancer patients and 168 age- and sex-matched controls were included as the study subjects. Information on smoking habit was collected using a self-administered questionnaire, and CYP1A1 and GSTP1 genotypes were analyzed using PCR-RFLP method. Chi-square test, Student's t-test and conditional logistic analysis were used to test statistical significance.
RESULTS
Smoking was turned out to be a significant risk factor of laryngeal cancer both in univariate and multivariate analyses. The CYP1A1 Ile/Ile genotype was significant in the univariate test, but the statistical significance disappeared in the multivariate conditional logistic model including smoking. The odds ratio (95% confidence interval) of GSTP1 A/A genotype for laryngeal cancer was 0.71 (0.38, 1.33), which was not statistically significant.
CONCLUSION
Smoking is the most potent risk factor among the three factors, and the genotypes of CYP1A1 and GSTP1 would not be major risk factors for laryngeal cancer in Koreans.

Keyword

Laryngeal cancer; Smoking; Cytochrome P450 1A1 (CYP1A1); Glutathione S-transferase P1 (GSTP1)

MeSH Terms

Carcinogens
Case-Control Studies
Cytochrome P-450 CYP1A1*
Cytochrome P-450 Enzyme System
Genotype
Glutathione Transferase
Humans
Laryngeal Neoplasms*
Logistic Models
Metabolism
Multivariate Analysis
Odds Ratio
Polymorphism, Genetic*
Surveys and Questionnaires
Risk Factors
Smoke
Smoking
Tobacco Products
Carcinogens
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
Glutathione Transferase
Smoke