Chonnam Med J.  2001 Jun;37(2):141-147.

Long-term Clinical and Angiographic Follow-up in Young Patients with Coronary Artery Diseases under the Age of 40

• Lee SU
• Jeong MH
• Park JC
• Park HW
• Cho SH
• Kim W
• Kim KH
• Lee SH
• Kang KT
• Cho JH
• Kim NH
• Kim KH
• Ahn YK
• Cho JG
• Park JC
• Kang JC

Abstract

Recently the incidence of coronary artery disease in young age has been increased in Korea, which may be related with the changes in dietary habit, stress and smoking. Etiologies, clinical characteristics, long-term follow-up results, and prognosis were assessed in young patients under the age of 40 after coronary interventions. From January 1996 to June 1999, 83 patients (36+/-4.2 year-old, male: female= 75:8), who underwent coronary angiogram for coronary artery disease under the age of 40, were evaluated retrospectively. Clinical diagnosis, risk factors, laboratory and coronary angiographic findings, predictive factors for restenosis and major adverse cardiac events (MACE) were analyzed. Mean follow-up duration was 24+/-22 months. The most common clinical diagnosis was acute myocardial infarction (42 cases, 50.6%) and risk factor was smoking (63 cases, 75.9%). The number of involved vessel was single vessel disease in 57 cases (68.5%) with the stenosis of left anterior descending coronary artery (LAD) in 26 cases (31.3%). Therapeutic modalities were conventional balloon angioplasty in 27 cases (32.5%), medical treatment in 26 cases (31.3%), stenting in 24 cases (28.9%) and coronary artery bypass graft in 6 cases (7.3%). Follow-up coronary angiogram was underwent in 42 cases out of 51 cases and restenosis was observed 21 cases. Predictive factors for restenosis were smoking and apolipoprotein (Apo) B level (p<0.05) and predictors for MACE (10 cases, 12.0%) were smoking and stenosis in the proximal LAD. The most important risk factor for coronary artery disease in young Korean patients is smoking and predictive factors of restenosis after coronary intervention are smoking and high Apo B.

Keyword

Coronary Artery Disease; Young age; Percutaneous Coronary Intervention; Restenosis

MeSH Terms

Angioplasty, Balloon
Apolipoproteins
Apolipoproteins B
Constriction, Pathologic
Coronary Artery Bypass
Coronary Artery Disease*
Coronary Vessels*
Diagnosis
Follow-Up Studies*
Food Habits
Humans
Incidence
Korea
Male
Myocardial Infarction
Percutaneous Coronary Intervention
Prognosis
Retrospective Studies
Risk Factors
Smoke
Smoking
Stents
Transplants
Apolipoproteins
Apolipoproteins B
Smoke