Korean J Obstet Gynecol.  2012 Nov;55(11):822-829. 10.5468/KJOG.2012.55.11.822.

Effect of feed restriction during gestation and lactation period on changes in organ weight in rat offspring

Affiliations
  • 1Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. kkyj@ewha.ac.kr
  • 2Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.
  • 3Department of Molecular Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
  • 4Neodin Medical Institute, Seoul, Korea.

Abstract


OBJECTIVE
We examined the effect of maternal feed restriction during gestation and lactation period on changes in liver, spleen, lung and brain weight in 3 and 24-week-old rat offspring.
METHODS
At day 10 of gestation, rats were divided into two groups and given an ad libitum (AdLib) diet or 50% food restricted (FR) diet until delivery. Offspring were divided into four groups: AdLib/AdLib, AdLib throughout experimental period; FR/AdLib, FR during pregnancy and AdLib after delivery; AdLib/FR, AdLib during pregnancy and FR after delivery; and FR/FR, FR throughout experimental period. Offspring were killed at 3 and 24 weeks of age.
RESULTS
In the FR/AdLib group, all of the organ's weights were not differed among the four groups in the 3 and 24-week-old offspring. In the AdLib/FR group, liver (P<0.01) and spleen (P<0.001) weight were decreased in the 3-week-old offspring, but these weights were not differed in the 24-week-old offspring. In this group, male's lung weight was not differed but female's lung (P<0.05) weight was higher than in the control group, however, lung weight of 24-week-old male offspring was increased (P<0.01) whereas female was not differed. Brain weight of AdLib/FR group was higher in the 3 (P<0.001) and 24-week-old (P<0.001 in male, P<0.01 in female) offspring than in the control group.
CONCLUSION
Our results indicate that maternal feed restriction during critical period might impact on the normal growth and development of offspring organs and also, these effects may influence to prevalence of disease in offspring's lifelong period.

Keyword

Maternal food restriction; Pregnancy; Lactation; Offspring; Organ weight
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