Korean J Obstet Gynecol.  2003 Sep;46(9):1707-1713.

The Expression of c-Src and Csk in the Human Endometrium During the Normal Menstrual Cycle

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Daejeon, Korea.
  • 2Assisted Reproductive Technology Clinic, College of Medicine, Konyang University, Daejeon, Korea.
  • 3Department of Pathology, College of Medicine, Konyang University, Daejeon, Korea.

Abstract


OBJECTIVE
The purpose of this study was to investigate the transcriptional expression and translational localization of c-Src and Csk, related to signal transduction of cell growth, differentiation, death, and DNA synthesis in the human endometrium during the normal menstrual cycle.
METHODS
The specimens were obtained from the hysterectomized uterus and endometrial biopsies that showed no endometrial pathology. The mRNA level of c-Src and Csk were examined by RT-PCR and the expression of these proteins were confirmed by immunohistochemistry.
RESULTS
The c-Src mRNA was strongly expressed at all phases, except in late secretory phase. The Csk mRNA was highly expressed at all phases. In stromal cells and glandular cells, immunohistochemical expression of c-Src protein was moderate in proliferative phase and was strong in the secretory phase. The expression of Csk protein was strong at all phases and more intensive in glandular cell than stromal cell.
CONCLUSION
It is suggested that c-Src may play an important role in the signaling of the differentiation of the human endometrium and the Csk may modulate the c-Src kinase activity.

Keyword

c-Src; Csk; Endometrium; Menstrual cycle
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr