Korean J Med.
2009 Aug;77(Suppl 1):S128-S133.
A case of osteomalacia due to vitamin D deficiency in a 36-year-old woman
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. chung@chonnam.ac.kr, JDJCJR@Chol.Com
- 2Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
Abstract
- Osteomalacia is characterized by defective mineralization of bone tissue, which leads to an accumulation of unmineralized bone matrix. The various potential causes of osteomalacia include vitamin D-associated metabolic disorders, absorption disorders, cancer, and drugs. While reports of osteomalacia caused by nutritional deficiency and inadequate sunlight exposure are rare in Korea, we recently experienced a case of osteomalacia due to vitamin D deficiency in a 36-year-old woman. The patient was a strict vegetarian, and over the previous 3 years, she had worked solely at night and reported suffering from multiple bone pain for 6 months. Dual-energy X-ray absorptiometry revealed a T-score of -4.9 and Z-score of -4.5 at the lumbar portion of the spine (L1-4). The serum 25(OH)D level was 7.6 ng/mL, and an iliac bone biopsy showed increased osteoid thickness compatible with osteomalacia. The patient's symptoms of generalized bone pain improved after vitamin D and calcium supplementation.
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