Korean J Med.
2008 Nov;75(5):564-568.
A case of acute drug-induced hepatotoxicity after albendazole treatment
- Affiliations
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- 1Department of Internal Medicine, Kangdong Sacred Heart Hospital, College of Medicine Hallym University, Seoul, Korea. mkjang2@medimail.co.kr
- 2Department of Pathology, Kangdong Sacred Heart Hospital, College of Medicine Hallym University, Seoul, Korea.
Abstract
- Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole-induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only.
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