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Development and Validation of a Simple Index Based on Non-Enhanced CT and Clinical Factors for Prediction of Non-Alcoholic Fatty Liver Disease

Ahn Y, Yun SC, Lee SS, Son JH, Jo S, Byun J, Sung YS, Kim HS, Yu ES

OBJECTIVE: A widely applicable, non-invasive screening method for non-alcoholic fatty liver disease (NAFLD) is needed. We aimed to develop and validate an index combining computed tomography (CT) and routine clinical...
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Signal Detection of Adverse Events Following Pneumococcal Vaccines from the Korea Adverse Event Reporting System Database, 2005–2016

Kim KS, Oh IS, Kim HJ, Song I, Park MS, Shin JY

PURPOSE: We aimed to analyze the surveillance reports of adverse events (AEs) due to different types of pneumococcal vaccines, in addition to detecting and validating signals of pneumococcal vaccines by...
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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

Ting WT, Chang RW, Wang CH, Chen YS, Lee JJ

Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was...
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Gastric Ulcers with Cytomegalovirus Infection in an Immunocompetent Patient

Kim TO, Shim KN, Kim SY, Lim JY, Choe AR, Tae CH, Moon CM, Kim SE, Jung HK, Jung SA

Cases of cytomegalovirus (CMV) infection are rare, and this infection is commonly asymptomatic in immunocompetent patients. Here, we report a pathologically proven case of CMV infection in gastric ulcers in...
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Aripiprazole-induced Hepatitis: A Case Report

Castanheira L, Fernandes , Levy P, Coentre R

Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and...
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Noninvasive Serum Fibrosis Markers are Associated with Coronary Artery Calcification in Patients with Nonalcoholic Fatty Liver Disease

Song DS, Chang UI, Kang SG, Song SW, Yang JM

BACKGROUND/AIMS: Advanced hepatic fibrosis is associated with cardiovascular disease (CVD) in patients with nonalcoholic fatty liver disease (NAFLD). We investigated the association between noninvasive serum fibrosis markers and the coronary...
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Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1

Zhang P, Yu J, Gui Y, Sun C, Han W

PURPOSE: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the...
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Serum Aminotransferase Level in Rhabdomyolysis according to Concurrent Liver Disease

Jo KM, Heo NY, Park SH, Moon YS, Kim TO, Park J, Choi JH, Park YE, Lee J

BACKGROUND/AIMS: The serum aminotransferase level is usually elevated in rhabdomyolysis, and these enzymes originate from the skeletal muscle. On the other hand, there is limited data showing whether the degree...
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Durability of Sustained Virologic Response and Improvement of Fibrosis Markers after Daclatasvir and Asunaprevir Treatment in Genotype 1b Hepatitis C Virus-Infected Patients: a Real Life and Multicenter Study

Shin SK, Lee JW, Ra H, Kwon OS, Shin JB, Jin YJ, Lee S, Han KJ, Kim YN, Kim TH, Kim YS, Kim JH

BACKGROUND: The long-term data with direct acting antiviral agents were rare. This study investigated the durability of a sustained virologic response (SVR) and the improvement of fibrosis after daclatasvir and...
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Improvement in histology, enzymatic activity, and redox state of the liver following administration of Cinnamomum zeylanicum bark oil in rats with established hepatotoxicity

Niknezhad , Sayad-Fathi S, Karimzadeh A, Ghorbani-Anarkooli M, Yousefbeyk F, Nasiri E

Formaldehyde (FA) is an environmentally-available pollutant. Since the liver acts as a detoxifier in the human body, it is the first and most affected organ in individuals exposed to higher-than-normal...
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Comparative study of liver injury induced by high-fat methionine- and choline-deficient diet in ICR mice originating from three different sources

Lee S, Kwak JH, Kim SH, Jeong TB, Son SW, Kim JH, Lim Y, Cho JY, Hwang DY, Kim KS, Jung YS

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...
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Correlation between synthesis of α2-macroglobulin as acute phase protein and degree of hepatopathy in rats

Ito R, Kuribayashi T

The degree of hepatopathy affecting the synthesis of α2-macroglobulin (α2M) as an acute phase protein in rats was investigated. Hepatopathy was induced in Sprague-Dawley rats by intravenous administration of galactosamine...
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Comparative analysis of unperforated and perforated appendicitis in laboratory values of patients who visited emergency center

Cho D, Seo JY

OBJECTIVE: Unperforated and perforated acute appendicitis need to be differentiated because appendicitis with a free perforation requires an emergency operation to prevent contamination inside the bowel from spreading into the...
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Predictive factors for gangrene complication in acute calculous cholecystitis

Shirah BH, Shirah HA, Saleem MA, Chughtai M, Elraghi MA, Shams ME

BACKGROUNDS/AIMS: Gallbladder gangrene is a grave complication of acute calculous cholecystitis that is difficult to detect preoperatively. Ultrasound could show a gallbladder wall that is more thickened. In addition, other...
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Utility of liver function tests in acute cholecystitis

Zgheib H, Wakil C, Shayya S, Mailhac A, Al-Taki M, El Sayed M, Tamim H

BACKGROUNDS/AIMS: Common bile duct stones (CBDS) affect the management of acute cholecystitis (AC). This study aims to investigate the utility of liver function tests (LFTs) in predicting the presence of...
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Safety Evaluation of Paclitaxel-Eluting Biliary Metal Stent with Sodium Caprate in Porcine Biliary Tract

Jang SI, Jeong S, Lee DH, Na K, Yang S, Lee DK

BACKGROUND/AIMS: Metallic stents designed to relieve malignant biliary obstruction are susceptible to occlusive tumor ingrowth or overgrowth. In a previous report, we described metallic stents covered with paclitaxel-incorporated membrane (MSCPM-I,...
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The comparison of desflurane and sevoflurane on postoperative hepatic function of infant with biliary atresia undergoing Kasai operation

Lee J, Kim MS, Lee HM, Lee JR, Park JH

BACKGROUND: Biliary atresia is an extrahepatic progressive obliterate cholangiopathy that occurs in infants. Kasai procedure, a surgical method that can help re-establish bile flow from the liver into the intestine,...
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Factors Affecting the Response to First-Line Treatments in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Zhang X, Wang C, Zhu W, Wang B, Liang H, Guo S

BACKGROUND AND PURPOSE: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis. This study aimed to explore the possible factors affecting the response to first-line treatments in...
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Evaluation of the Analytical Performance of Atellica CH 930 Automated Chemistry Analyzer

Kim D, Cho Y, Cho J, Kim SH, Lee SG, Kim JH

BACKGROUND: Recently, a new automated chemistry analyzer, Atellica CH930 (Siemens, Germany), was introduced. It automatically measures internal quality control (QC) materials according to a pre-determined schedule. For this purpose, the...
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Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats

Kwon KW, Nam Y, Choi WS, Kim TW, Kim GM, Sohn UD

Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in...
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