Korean J Nephrol.
1998 Mar;17(2):340-347.
Churg-Strauss Syndrome with Acute Renal Failure in a Patient without Asthma
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Churg-Strauss syndrome(allergic granulomatosis and angiitis) is a distinct entity composed of fever, eosinophilia, systemic vasculitis of multiple organ systems, and pathologically eosinophilic infiltration, granuloma and necrotizing vasculitis. In most cases it develops in patients with asthma, and renal involvement is characteristically mild and acute renal failure is rare in contrast to other systemic vasculitides. We report an unusual case of Churg-Strauss syndrome manifested by acute renal failure as well as fever, rash, eosinophilia, and nonfixed pulmonary infiltrates in a patient without history of asthma but with that of allergic contact dermatitis. Renal biopsy revealed interstitial eosinophil infiltration, glomerular, vascular and perivascular granulomas containing giant cells. Fever, eosinophilia, and acute renal failure improved immediately after prednisolone 1mg/kg/day demonstrating good response to steroid as in previous reports.
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