Korean J Asthma Allergy Clin Immunol.  2012 Sep;32(3):193-197.

A Case of Churg-Strauss Syndrome with Acute Renal Failure

Abstract

BACKGROUND
Churg-Strauss syndrome is a rare systemic disorder characterized by bronchial asthma, hypereosinophilia and systemic vasculitis. The prevalence and severity of renal involvement in patients with Churg-Strauss syndrome is not well known. We report a rare case of a patient with Churg-Strauss syndrome accompanied by acute renal failure. CASE HISTORY: A 52-year-old woman with skin rash and generalized edema was admitted to our hospital via the emergency room. She had a 7-year history of bronchial asthma and allergic rhinitis. Laboratory evaluation showed marked eosinophilia, elevated creatinine, and heavy proteinuria. She was positive for anti-neutrophil cytoplasmic antibody. Computed tomography of chest and paranasal sinuses revealed pulmonary infiltration and pansinusitis. Peripheral neuropathy was confirmed and small vasculitis was noted in a skin biopsy specimen.
RESULTS
She was diagnosed with Churg-Strauss syndrome and showed rapidly progressive renal insufficiency despite systemic corticosteroid administration. Oilguria was aggravated, and hemodialysis was thereafter started. Despite 2 weeks of continuous hemodialysis, her renal function was not improved.
CONCLUSION
We report a rare case of Churg-Strauss syndrome associated with acute renal failure. A long-term follow-up is needed in Churg-Strauss syndrome patients.

MeSH Terms

Acute Kidney Injury
Antibodies, Antineutrophil Cytoplasmic
Asthma
Biopsy
Churg-Strauss Syndrome
Creatinine
Edema
Emergencies
Eosinophilia
Exanthema
Female
Humans
Middle Aged
Paranasal Sinuses
Peripheral Nervous System Diseases
Prevalence
Proteinuria
Renal Dialysis
Renal Insufficiency
Rhinitis
Rhinitis, Allergic, Perennial
Skin
Systemic Vasculitis
Thorax
Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Creatinine