Korean J Hematol.  2009 Jun;44(2):104-107. 10.5045/kjh.2009.44.2.104.

Primary Diffuse Large B Cell Lymphoma of the Bladder

• Kim SK
• Kim MH
• Lee N
• Cha D
• Kim H
• Choi YJ
• Chung JS
• Cho GJ

• KMID: 2252155
• DOI: http://doi.org/10.5045/kjh.2009.44.2.104

Abstract

Primary malignant lymphoma of the urinary bladder is a rare disease, and it accounts for only 0.2% of all the cases of extranodal lymphoma. The prognosis of primary bladder lymphoma has been favorable, with many patients being alive and well several years after treatment. We report here on a case of primary diffuse large B cell lymphoma of the urinary bladder in a 75-year-old man patient who presented with a one-month history of persistent dysuria. The abdominal CT revealed a mass at the posterior wall of the urinary bladder. The tissue obtained by transurethral cystoscopy showed an atypical lymphoid proliferation, which was consistent with diffuse large B cell lymphoma. The patient received systemic chemotherapy of rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and he achieved a significant partial remission.

Keyword

Urinary bladder; Primary; Diffuse large B cell lymphoma

MeSH Terms

Aged
Antibodies, Monoclonal, Murine-Derived
Cystoscopy
Doxorubicin
Dysuria
Humans
Lymphoma
Lymphoma, B-Cell
Prognosis
Rare Diseases
Urinary Bladder
Vincristine
Rituximab
Antibodies, Monoclonal, Murine-Derived
Doxorubicin
Vincristine

Figure

• 

  Fig. 1. Abdominal CT scan finding. (A) Marked wall thickening of bladder wall and soft tissue mass around both distal ureter. (B) Significant interval decrease in the size of lobulated mass in bladder and bladder wall thickening.

• 

  Fig. 2. Microscopic findings of mass at posterior wall of urinary bladder. (A) Atypical lymphoid proliferations consistent with diffuse large B cell lymphoma (H&E stain, ×400). (B) Immunohistochemically, tumor cells show strong positivity for the B-cell marker (L26 stain, ×400). (C) Immunohistochemically, tumor cells show strong positivity for the leukocyte common antigen (LCA) (LCA stain, ×400).

Reference

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