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Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice

Kwon MH, Choi MJ, Liu FY, Fridayana FR, Niloofar L, Yin GN, Ryu JK

Purpose: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice. Methods: Eight-week-old C57BL/6 mice were...
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Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression

Daei S, Ziamajidi N, Abbasalipourkabir R, Aminzadeh Z, Vahabirad M

Bladder cancer is defined as a urinary tract malignancy that threatens men’s and women’s health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome...
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Diagnosis and Treatment of Urinary Incontinence in Female Patients

Shin JH

Urinary incontinence (UI), an involuntary loss of urine, is classified by clinical situation. The most common UI cases include stress UI (SUI), the involuntary loss of urine on effort or...
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Laparoscopic radical cystectomy with pelvic lymph node dissection and ileal orthotopic neobladder by a total extraperitoneal approach: Our initial technique and short-term outcomes

Zhu G, Zhang Z, Zhao K, Yin X, Zhang Y, Wang Z, Li C, Sui Y, Li X, Yang H, Xing N, Wang K

Purpose: With the increasing application of laparoscopic or robot-assisted radical cystectomy, a reliable and promising method is needed for reducing postoperative complications. We describe the short-term outcomes of totally extraperitoneal...
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External validation of European Association of Urology NMIBC risk scores to predict progression after transurethral resection of bladder tumor in Korean patients with non-muscle-invasive bladder cancer

Kim JY, Lee DB, Song WH, Lee SS, Park SW, Nam JK

Purpose: This study aimed to validate the newly proposed risk model in Korean patients diagnosed with non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: A retrospective review was performed with 1,238 patients...
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A novel strategy for treatment of bladder cancer: Antibody-drug conjugates

Kim JH, Chang IH

In the past, there was no second-line chemotherapeutic agent suitable for use when urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several new treatment options, such as immune checkpoint...
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Clinically undetected plasmacytoid urothelial carcinoma of the urinary bladder with non-mass-forming metastases in multiple organs: an autopsy case

Asano Y, Miyai K, Yoshimatsu S, Sasaki M, Ikewaki K, Matsukuma S

This case report outlines a clinically undetected urinary bladder plasmacytoid urothelial carcinoma (PUC) with multiple metastases detected at autopsy. An 89-year-old man presented with edema in the lower limbs. Pleural...
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Genomic Sequencing for Bladder Urothelial Carcinoma and Its Clinical Implications for Immunotherapy

Kim R, Hong JY, Lee J, Kwon GY, Jeong BC, Park SH

Purpose This study aimed to explore the genomic and transcriptomic landscape of bladder cancer (BC) and its implication for treatment with an immune checkpoint inhibitor (ICI). Materials and Methods We analyzed...
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Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis

Suh J, Han D, Ku JH, Kim HH, Kwak C, Jeong CW

Purpose We aimed to identify, verify, and validate a multiplex urinary biomarker-based prediction model for diagnosis and surveillance of urothelial carcinoma of bladder, using high-throughput proteomics methods. Materials and Methods Label-free quantification...
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The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey

Moon S, Kim YJ, Chung HS, Yu JM, Park II, Park SG, Pak S, Kwon O, Lee YG, Cho ST

Purpose: We investigated the relationship between nocturia and mortality risk in the United States. Methods: Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained...
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Efficacy and Safety of DA-8010, a Novel M3 Antagonist, in Patients With Overactive Bladder: A Randomized, Double-Blind Phase 2 Study

Son HS, Oh CY, Choo MS, Kim HG, Kim JC, Lee KS, Shin DG, Cho SY, Jeong SJ, Seo JT, Yoon H, Moon HS, Kim JH

Purpose: DA-8010 is a novel muscarinic M3 receptor antagonist with significant selectivity for bladder over salivary gland in preclinical studies. We evaluated the clinical efficacy and safety of DA-8010 in...
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Bladder Cancer Metastasis to the Breast in a Male Patient: Imaging Findings on Mammography and Ultrasonography

Yoon IN, Cha ES, Kim JH, Lee JE, Chung J

Male breast cancer is rare, accounting for approximately 1% of breast cancers. Metastasis from extra-mammary malignancy to the breast in men is extremely rare. The most common primary tumors that...
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The Prevalence of Lower Urinary Tract Symptoms and Overactive Bladder in South Korea: A Cross-Sectional, Population-Based Study

Kim MK, Shin YS, Lee JH, Cho WJ, Kim DK

Purpose: Lower urinary tract symptoms (LUTS) affect over half of the adults’ population worldwide, with an increasing prevalence among the older age groups. Therefore, with the increasing elderly population, LUTS...
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Comparison of outcomes between pessary use and surgery for symptomatic pelvic organ prolapse: A prospective self-controlled study

Linder BJ, Gebhart JB, Weaver AL, Fick FR, Harvey-Springer RR, Trabuco EC, Klingele CJ, Occhino JA

Purpose: We compared the degree of pelvic floor symptom improvement between pessary use and prolapse surgery. Materials and Methods: Pessary-naïve women who elected prolapse surgery were enrolled and used a pessary...
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Low-dose versus standard-dose bacille Calmette–Guérin for non-muscle-invasive bladder cancer: Systematic review and meta-analysis of randomized controlled trials

Choi SY, Ha MS, Kim JH, Chi BH, Kim JW, Chang IH, Kim TH, Myung SC

Purpose: Intravesical BCG (bacille Calmette–Guérin) instillation in patients with non-muscle-invasive bladder cancer decreases the risk for tumor recurrence and progression. After one BCG product was discontinued, a chronic global BCG...
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Diagnostic Value of the Maximum Urethral Closing Pressure in Women With Overactive Bladder Symptoms and Functional Bladder Outlet Obstruction

Kim SJ, Choo HJ, Yoon H

Purpose: Overactive bladder (OAB) is observed in women with functional bladder outlet obstruction (FBOO), as are lower urinary tract symptoms (LUTS). Therefore, we evaluated the urodynamic characteristics of women with...
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Inflammatory Myofibroblastic Tumor of the Urinary Bladder in a Young Patient With Gross Hematuria: A Case Report

Chae HK, Nam W, Kim SJ, Noh BJ, Park JY

Inflammatory myofibroblastic tumor (IMT) of the urinary bladder is an uncommon disease in young patients that presents with gross hematuria. However, IMT should be cautiously diagnosed because of its similarities...
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Clinical Significance of Rab27a as a Urinary Biomarker in Patients With Bladder Cancer

Ku JY, Hwang EC, Lee CH, Kim KH, Kwon DD, Ha HK

Purpose: The aims of this study were to investigate the clinical value of Rab27a as a urinary biomarker, and its efficiency in the prediction of bladder cancer grade. Materials and Methods:...
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De Ritis Ratio, Neutrophil-to-Lymphocyte Ratio, and Albumin Are Significant Prognostic Factors for Survival Even After Adjusted by the Treatment Duration in Metastatic Kidney and Bladder Cancer Treated With Immune-Checkpoint Inhibitors

Kim SH, Park EY, Lee HH, Chung J, Seo HK

Purpose: This study aimed to determine the prognostic roles of several immune-related laboratory parameters in patients with metastatic kidney and bladder cancer treated with immune checkpoint inhibitors (ICIs). Materials and Methods:...
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New Drugs for Bacillus Calmette Guérin-Unresponsive Nonmuscle Invasive Bladder Cancer

Jeong J, Ha JB, Chang IH

For intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC), intravesical Bacillus Calmette-Guérin (BCG) therapy is the standard adjuvant treatment following transurethral resection of bladder tumor. Although intravesical BCG therapy improves...
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