Korean J Gastroenterol.  2000 Mar;35(3):343-348.

Incidence of Hepatocellular Carcinoma and Cumulative Long-term Survival Rate in Patients with Membranous Obstruction of Inferior Vena Cava

• Lee JH
• Lee KH
• Lee DH
• Kim TH
• Woo GH
• Kim JW
• Yoon JH
• Jung HC
• Lee HS
• Song IS
• Kim CY

Abstract

Membranous obstruction of inferior vena cava (MOIVC) has been known as one of the risk factors for hepatocellular carcinoma (HCC). However, the incidence of HCC in patient with MOIVC or the effect of treament on the natural history of the patients has not yet been evaluated. The present study was to analyze the incidence of HCC and the survival rate, and then, to determine whether treatment may modify the clinical course.
METHODS
The medical records of 39 patients diagnosed as MOIVC at Seoul National University Hospital from December 1984 to November 1997 were retrospectively analyzed.
RESULTS
Seven patients had HCC at the time of diagnosis. We performed angioplasty for 21 of the rest patients, surgery for 4, and supportive care for 7. The 5- and 10-year survival rates of all patients were 90% and 69%, respectively. The 1-, 2- and 7-year incidence of HCC was 5%, 11% and 26%, respectively. The 10-year survival rates of treated and non-treated patients were 75% and 66%, respectively (p>0.05). The 5-year incidence of HCC in treated and non-treated patients was 14% and 0%, respectively (p>0.05).
CONCLUSIONS
The treatment of MOIVC did neither increase survival rate nor prevent the development of HCC. Therefore, the efficacy of treatment for MOIVC should be reevaluated and patients should be followed up for the detection of HCC.

Keyword

Membranous obstruction of inferior vena cava; Hepatocellular carcinoma; Survival rate; Incidence; Angioplasty

MeSH Terms

Angioplasty
Carcinoma, Hepatocellular*
Diagnosis
Humans
Incidence*
Medical Records
Natural History
Retrospective Studies
Risk Factors
Seoul
Survival Rate*
Vena Cava, Inferior*