Korean J Gastroenterol.  2000 May;35(5):568-578.

Long-Term Follow-up of Patients with Low-Grade Mucosa-associated Lymphoid Tissue Gastric Lymphoma after Eradication of Helicobacter pylori

• Kim YS
• Lee CH
• Choi IJ
• Kim JS
• Kim TH
• Lee KL
• Lee DH
• Jung HC
• Kim CW
• Song IS
• Kim CY

Abstract

BACKGROUND/AIMS
We performed this prospective study to evaluate the long-term outcome of patients with low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma after H. pylori eradication. We also investigated the relationship between p16 hypermethylation and the remission of MALT lymphoma in the patients.
METHODS
We prospectively enrolled 21 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage IE1). The patients received the eradication therapy of H. pylori and then, follow-up endoscopic and histologic examinations were performed at regular intervals. Methylation-specific polymerase chain reaction (MSP) method was used for the serial detection of p16 hypermethylation.
RESULTS
Nineteen patients (90.5%) achieved complete remission and their median duration of remission was 15.7 months. One patient had a relapse of MALT lymphoma for two times. Seven patients (58%) revealed p16 hypermethylation initially and in 3 patients who were followed-up for median 28 months, p16 hypermethylation was disappeared.
CONCLUSIONS
Complete remission of low-grade gastric MALT lymphoma after H. pylori eradication could be maintained in long-term period. Further studies are needed to investigate a role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma.

Keyword

MALT lymphoma; H. pylori; p16 hypermethylation

MeSH Terms

Follow-Up Studies*
Helicobacter pylori*
Helicobacter*
Humans
Lymphoid Tissue*
Lymphoma*
Lymphoma, B-Cell, Marginal Zone
Polymerase Chain Reaction
Prospective Studies
Recurrence