Korean J Gastroenterol.  2016 Oct;68(4):175-178. 10.4166/kjg.2016.68.4.175.

Gastric Mucosa-associated Lymphoid Tissue Lymphoma Based on Outcome of Domestic Treatment

Affiliations
  • 1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jungjt@cu.ac.kr

Abstract

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is associated with Helicobacter pylori infection. H. pylori eradication can be performed as a primary therapy regardless of H. pylori status. In Korea, six articles were published about low-grade gastric MALT lymphoma with H. pylori. Complete regression rate after H. pylori eradication is reported at 74.5% to 94.4%. Radiotherapy results in favorable clinical long-term outcomes in patients with early-stage gastric MALT lymphoma who fail H. pylori eradication therapy and those who are H. pylori negative. Chemotherapy could be reserved for patients with metastatic or high-grade lymphoma. In gastric MALT lymphoma, patients with polypoid type on initial endoscopy had a higher likelihood of recurrence than those with diffuse infiltration or ulceration types. The depth of invasion, location of lesions, and chromosomal abnormality with t(11;18) together are predictive factors for failure to remission by H. pylori eradication.

Keyword

Mucosa-associated lymphoid tissue; Stomach; Therapy

MeSH Terms

Chromosome Aberrations
Drug Therapy
Endoscopy
Helicobacter pylori
Humans
Korea
Lymphoid Tissue
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Lymphoma, Non-Hodgkin
Radiotherapy
Recurrence
Stomach
Ulcer
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