Korean J Gastroenterol.
2000 Jul;36(1):1-9.
Pharyngoesophageal Motility in Patients with Globus Sensation
Abstract
- BACKGROUND/AIMS
It has been considered that motor abnormalities
of the oropharynx might play some roles in the pathogenesis of globus sensation.
This study was aimed to evaluate motor abnormality of the upper esophageal sphincter
(UES) and pharynx.
METHODS
Fifty-three patients with globus sensation in throat
and twenty healthy subjects underwent a circumferential solid state manometry.
The measured manometric parameters were as follows : basal UES pressure,
% UES relaxation, timing of UES relaxation (T1, time interval from the onset
of hypopharyngeal contraction to the onset of UES relaxation; T2, time interval
from the onset to the completion of UES relaxation), contracting tongue base pressure,
contracting hypopharyngeal pressure, intrabolus pressure area (IBPA), prevalence
of peristalsis (POP), amplitude of distal esophageal contraction, and basal LES
pressure. Then, differences of these parameters in both groups were analysed.
RESULTS
The mean values of T2 and IBPA were high and POP was decreased
in the patients group. Moreover, there was a significant correlation between
T2 and IBPA.
CONCLUSIONS
Globus sensation might be associated with a prolonged
time interval from the onset to completion of UES relaxation, an increased IBPA,
and a decreased POP of the esophageal body.