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Pitavastatin Induces Apoptosis of Cutaneous Squamous Cell Carcinoma Cells through Geranylgeranyl PyrophosphateDependent c-Jun N-Terminal Kinase Activation

Kim KI, Kim SM, Lee YY, Lee Y, Kim CD, Yoon TJ

Background: Pitavastatin is a cholesterol-lowering drug and is widely used clinically. In addition to this effect, pitavastatin has shown the potential to induce apoptosis in cutaneous squamous cell carcinoma (SCC)...
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Pretransplant C-reactive protein-to-albumin ratio predicts mortality in kidney transplant recipients: a retrospective cohort study

Kwon JW, Jeon Y, Jung HY, Choi JY, Park SH, Kim CD, Kim YL, Hwang D, Yun WS, Kim HK, Huh S, Yoo ES, Won DI, Cho JH, Lim JH

Background: The C-reactive protein (CRP)-to-albumin ratio (CAR) is a more effective prognostic indicator than CRP or albumin alone in various diseases. This study aimed to evaluate the predictive value of...
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Immunohistochemical Expression of Yes-Associated Protein in Koreans with Acral Melanomas

Kim SM, Kim D, Kwon IS, Shin JM, Hong D, Jung KE, Kim CD, Lee Y, Seo YJ, Park S

  • KMID: 2538562
  • Korean J Dermatol.
  • 2022 Dec;60(10):657-665.
Background: Acral melanoma is the most common subtype of melanoma among Koreans, and regional or distant metastasis is an indicator of poor prognosis. Yes-associated protein (YAP), a key effector of...
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Effect of Activating Transcription Factor 3 on Inflammatory Response and Differentiation of Keratinocytes

Kim K, Kim D, Shin JM, Hong D, Jung KE, Seo YJ, Lee Y, Kim CD

  • KMID: 2538560
  • Korean J Dermatol.
  • 2022 Dec;60(10):640-646.
Background: Pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune responses. Genetic background is one of the most important factors in disease pathogenesis. However, psoriasis-associated genes have not...
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Urine exosomal bkv-miR-B1-5p and BK virus nephropathy in kidney transplant recipients

Jung SW, Cho WH, Seo JW, Kim JS, Kim CD, Chung BH, Park JB, Kim YH, Lee SH

Background: Urine exosomal bkv-miR-B1-5p was associated with BK virus (BKV) nephropathy (BKVN), but its serial post-transplantation changes and predictability for BKVN have not been determined in kidney transplant recipients (KTRs). Methods:...
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Pretransplant C-reactive protein-to-albumin ratio predicts mortality in kidney transplant recipients: a retrospective cohort study

Kwon J, Park SD, Jeon YH, Jung HY, Choi JY, Park SH, Kim CD, Kim YL, Cho JH, Lim JH

Background: C-reactive protein (CRP)-to-albumin ratio (CAR) has been reported as a more effective prognostic indicator than CRP or albumin alone in various diseases. However, the association between CAR and transplant...
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Successful provision of hemodialysis to patients with confirmed COVID-19 in Korea: the role of a cooperative network between public and private medical systems

Choi JY, Lim JH, Han S, Park SC, Jung HY, Cho JH, Kim CD, Kim YL, Park SH

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Screening of Plant-Derived Natural Extracts to Identify a Candidate Extract Capable of Enhancing Lipid Synthesis in Keratinocytes

Lee SH, Seo HS, Seo SJ, Kim CD, Hong SP

Background: Reduced lipid content in the stratum corneum is a major cause of skin-barrier dysfunction in various pathological conditions. Promoting lipid production is a potential strategy to improve skin-barrier function....
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HMGB1 increases RAGE expression in vascular smooth muscle cells via ERK and p-38 MAPK-dependent pathways

Jang EJ, Kim H, Baek SE, Jeon EY, Kim JW, Kim JY, Kim CD

The increased expression of receptors for advanced glycation endproduct (RAGE) is known as a key player in the progression of vascular remodeling. However, the precise signal pathways regulating RAGE expression in...
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Role of Substance P in Regulating Micro-Milieu of Inflammation in Alopecia Areata

Kim C, Shin JM, Kim D, Park S, Hong D, Jung KE, Kim CD, Seo YJ, Lee Y

Background: Alopecia areata (AA) is an autoimmune disease characterized by chronic inflammation, the pathogenesis of which is unknown. Stress is believed to play a role; however, evidence remains insufficient. A...
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A multicenter, randomized, open-label, comparative, phase IV study to evaluate the efficacy and safety of combined treatment with mycophenolate mofetil and corticosteroids in advanced immunoglobulin A nephropathy

Han SY, Jung CY, Lee SH, Lee DW, Lee S, Kim CD, Choi BS, Kim BS

Background: It remains unclear whether immunosuppressive agents are effective in patients with immunoglobulin A nephropathy (IgAN). We investigated the efficacy of a mycophenolate mofetil (MMF) and corticosteroid combination therapy in...
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Treatment of rituximab in patients with idiopathic membranous nephropathy: a case series and literature review

Jeon SJ, Kim JH, Noh HW, Lee GY, Lim JH, Jung HY, Cho JH, Choi JY, Kim CD, Kim YL, Park SH

Background/Aims: Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults. This study aimed to evaluate the effect of rituximab (RTX) in patients with idiopathic MN (iMN) who...
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Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts

Kim KI, Kwon CI, Lee JH, Kim CD, Yoon TJ

Background: Fibroblasts produce collagen molecules that support the structure of the skin. The decrease and hypersynthesis of collagen causes skin problems such as skin atrophy, wrinkles and scars. Objective: The purpose of...
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A Study on the Relationship between Facial Skin Youthfulness and Lifestyle in Korean Women over 50 Years Old

Kim SM, Lee YY, Hwang CL, Shin JM, Kwon IS, Park SH, Jung KE, Kim CD, Seo YJ, Hong D, Lee Y

  • KMID: 2530076
  • Korean J Dermatol.
  • 2022 May;60(4):201-208.
Background: Skin aging can be divided into intrinsic and extrinsic processes, and occur due to several factors. Although the interest in skin youthfulness is increasing globally, research on facial skin...
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Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection

Lim JH, Chung BH, Lee SH, Jung HY, Choi JY, Cho JH, Park SH, Kim YL, Kim CD

Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft...
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Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

Lim JH, Lee GY, Jeon Y, Jung HY, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Yoo ES, Won DI, Kim CD

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the...
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Activation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes

Jung YR, Shin JM, Kim CH, Kim S, Kim CD, Seo YJ, Lee JH, Im M, Lee Y, Lee YH

Background: Sebocytes are the main cells involved in the pathogenesis of acne by producing lipids and inflammatory cytokines. Although palmitic acid (PA) has been suggested to induce an inflammatory reaction,...
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Sodium-glucose cotransporter 2 inhibitors in kidney transplant recipients

Lim JH, Kwon S, Jung HY, Choi JY, Park SH, Kim CD, Kim YL, Lee JP, Cho JH

Background: The effect and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been investigated in kidney transplant recipients (KTRs) with diabetes. We evaluated the impact of SGLT2i in a...
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Azidothymidine Downregulates Insulin-Like Growth Factor-1 Induced Lipogenesis by Suppressing Mitochondrial Biogenesis and Mitophagy in Immortalized Human Sebocytes

Yoo JG, Li XM, Lee JK, Park S, Hong D, Jung KE, Lee Y, Seo YJ, Kim CD, Shin JM, Choi CW

Background: Increased sebum secretion is considered the main causative factor in the pathogenesis of acne. There is an unmet pharmacological need for a novel drug that can control sebum production...
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Hair Changes and Hair Care in Women Treated with Adjuvant Hormone Therapy for Breast Cancer: A Pilot Study

Lee JK, Kim CH, Hong D, Jung KE, Seo YJ, Kim CD, Lee JS, Kwon IS, Park S, Lee Y

  • KMID: 2519508
  • Korean J Dermatol.
  • 2021 Aug;59(7):521-526.
Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective:...
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