Korean J Gastroenterol.  2000 Mar;35(3):269-275.

Esophageal Manometry and 24 Hours Ambulatory Esophageal pH Monitoring in Patients with Globus Pharyngeus


BACKGROUND/AIMS: Globus sensation in throat is generally considered as psychiatric disorder, but its pathophysiology is still controversial. It has been reported that esophageal motility disorder and/or gastroesophageal reflux disease have a role in the pathogenesis of globus pharyngeus. The aim of this study was to evaluate whether any association exists among esophageal motility disorders, gastroesophageal reflux disease, and globus pharyngeus.
Thirty-seven patients with globus sensation were enrolled in this study. Esophageal manometry and 24 hours ambulatory esophageal pH monitoring were carried out.
Fifty-one percent (19 of 37 patients) demonstrated motility abnormality in esophageal body and lower esophageal sphincter (LES). The most common abnormality was non-specific esophageal motility disorder in 14 of the patients (38%). Two patients (5%) had nutcraker esophagus, 2 patients (5%) showed hypertensive LES, 1 patient (3%) had diffuse spasm. Abnormal gastro-esophageal reflux was noted in 5 patients (14%). It was revealed that 21 patients (57%) showed esophageal motility disorders and/or pathologic gastro-esophageal reflux.
There is a significant relation between esophageal motility disorders and/or gastro-esophageal reflux in patients with globus pharyngeus.


Globus pharyngeus; Esophageal motility disorder; Gastro-esophageal reflux
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