Korean J Anesthesiol.  1989 Feb;22(1):35-40. 10.4097/kjae.1989.22.1.35.

The Interaction of Pancuronium and Mannitol for the Muscle Relaxation in Rabbits

• Jun JH
• Lee C
• Kim KH
• Lee DH
• Kim KS
• Suh JK
• Yoo HK
• Seung IS
• Chon SU

• KMID: 2237910
• DOI: http://doi.org/10.4097/kjae.1989.22.1.35

Abstract

Pancuronium is one of the most available nondepolarizing musde relaxants. It is primarily elimianat-ed unchanged by the kidney, although a small fraction is metabolized by the liver.lndications for the use of mannitol are the prophylaxis of acute renal failure in conditions as diverse as cardiovascular operations, severe tramnatic injury, operations in the preaence of severe jaundice, and hemolytic transfusion reactions. It is also used for the reduction of intracranial pressure and volume of the cerebrospinal fluid in case of brain tumor and/or trauma of the brain. This study has been conducted to evaluate neuromuscular blocking effects of pancuronium in the rabbits after administration of mannitol. The results were as follows: 1) Recovery index by the pyridostigmine was 200.6 seconds in the study group which was given by mannitol and recovery index in the control group which was not given by mannitol, was 196.8 seconds. It appears to be no significant difference statistically in both groups. 2) Urine output was 54 ml in the study group and 10.3 ml in the control group. It appears to be significant difference statistically in both groups, but the results of electrolyte and arterial blood gas analysis lay within the normal limits in both groups.

Keyword

Muscle relaxant-pancuronium; Anticholinesterase-pyridostigmine; Diuretics-mannitol

MeSH Terms

Acute Kidney Injury
Blood Gas Analysis
Blood Group Incompatibility
Brain
Brain Neoplasms
Cerebrospinal Fluid
Intracranial Pressure
Jaundice
Kidney
Mannitol*
Muscle Relaxation*
Neuromuscular Blockade
Pancuronium*
Pyridostigmine Bromide
Rabbits*
Mannitol
Pancuronium
Pyridostigmine Bromide