Korean J Anesthesiol.  1991 Dec;24(6):1131-1137. 10.4097/kjae.1991.24.6.1131.

The Effect of Verapamil on Cardiovascular Response to Tracheal Intubation

• Park YC
• Ryu HH
• Baik SW
• Chung KS
• Choi IC

• KMID: 2237062
• DOI: http://doi.org/10.4097/kjae.1991.24.6.1131

Abstract

To evaluate the efficacy of verapamil to prevent sympathetic stimulation during endotracheal intubation. Author studied the cardiovascular responses to laryngoscopy and endoracheal intubation in 60 patients who received verapamil 0.075 mg/kg, 0.15 mg/kg or no verapamil medication before the larngoscopy. The index of'cardiovascular response during laryngoscopy and tracheal intubation were mean arterial pressure(MAP), heart rate(HR), and rate pressure product(RPP). And author concluded as follows. l) The changes of MAP were more stable in verapamil groups than no verapamil group(P 0.05). But there were no difference between verapamil 0.075 mg/kg and 0.15 mg/kg groups. 2) The changes of HR were more stable in verapamil group until 5 minutes after tracheal intubation. In difference between verapamil 0.015 mg/kg and 0.15 mg/kg, verapamil 0.15 mg/kg(P 0.01) were more stable than 0.075 mg/kg group(P 0.005). 3) The canges of RPP were more stable in verapamil group until 10 min. after tracheal intubation. But there were no difference in verapamil 0.075 mg/kg and 0.15 mg/kg group.

Keyword

Intubation; verapamil; RPP; Blood pressure; Heart rate

MeSH Terms

Blood Pressure
Heart
Heart Rate
Humans
Intubation*
Intubation, Intratracheal
Laryngoscopy
Verapamil*
Verapamil