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Cost-Effectiveness of Rate- and Rhythm-Control Drugs for Treating Atrial Fibrillation in Korea

Kim M, Kim W, Kim C, Joung B

PURPOSE: Although the economic and mortality burden of atrial fibrillation (AF) is substantial, it remains unclear which treatment strategies for rate and rhythm control are most cost-effective. Consequently, economic factors...
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Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats

Elberry AA, Sharkawi S, Wahba MR

BACKGROUND: Antinociceptive anti-inflammatory drugs have many adverse effects. The goal of this investigation is to study the probable anti-inflammatory and analgesic effects of verapamil and N-acetylcysteine (NAC) in experimental rats. METHODS:...
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The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat

Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD

Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder...
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The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats

Han JS, Min YS, Kim GH, Chae SH, Nam Y, Lee J, Lee SY, Sohn UD

Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors....
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A Portulaca oleracea L. extract promotes insulin secretion via a K⁺(ATP) channel dependent pathway in INS-1 pancreatic β-cells

Park JE, Han JS

BACKGROUND/OBJECTIVE: This study was designed to investigate how a Portulaca oleracea L. extract (POE) stimulates insulin secretion in INS-1 pancreatic β-cells. MATERIALS/METHOD: INS-1 pancreatic β-cells were incubated in the presence of...
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The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity

Ha DM, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Lim D, Kang C

PURPOSE: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated...
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Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Kim KM, Lee K, Jang K, Moon YS, Lee HJ, Rhie SJ

Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded...
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Treatment of Cerebral Vasospasm in an Infant Using a Modified Dotter Technique

Snelling B, Sur S, Shah SS, Peterson E

An 8-month old female presented with spontaneous subarachnoid hemorrhage and was treated successfully with endovascular coil embolization of the ruptured aneurysm. Transcranial Doppler ultrasound performed four days later demonstrated middle...
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Supraventricular Tachycardia by Concealed Bypass Tract

Lee KH

Concealed bypass tract (CBT) results from incomplete development of the atrioventricular (AV) annulus. CBT conducts only in a retrograde direction, and therefore does not cause pre-excitation on standard electrocardiograms. The...
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Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level

Choi MK, Song IS

This study aimed to investigate the in vivo relevance of P-glycoprotein (P-gp) in the pharmacokinetics and adverse effect of phenformin. To investigate the involvement of P-gp in the transport of...
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Severe Cerebral Vasospasm in Patients with Hyperthyroidism

Oh HJ, Yoon SM, Oh JS, Shim JJ, Bae HG

Cerebral vasospasm associated with hyperthyroidism has not been reported to cause cerebral infarction. The case reported here is therefore the first of cerebral infarction co-existing with severe vasospasm and hyperthyroidism....
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Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine

Ok SH, Bae SI, Kwon SC, Park JC, Kim WC, Park KE, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT

BACKGROUND: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated...
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Effects of C18 Fatty Acids on Intracellular Ca2+ Mobilization and Histamine Release in RBL-2H3 Cells

Kim MC, Kim MG, Jo YS, Song HS, Eom TI, Sim SS

To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and alpha-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on...
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Mepivacaine-induced intracellular calcium increase appears to be mediated primarily by calcium influx in rat aorta without endothelium

Ok SH, Kwon SC, Kang S, Choi MJ, Sohn JT

BACKGROUND: Mepivacaine induces contraction or decreased blood flow both in vivo and in vitro. Vasoconstriction is associated with an increase in the intracellular calcium concentration ([Ca2+]i). However, the mechanism responsible...
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Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells

Wang Z, Wang D, Li Y, Zhang X

Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the...
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Identification of P-Glycoprotein and Transport Mechanism of Paclitaxel in Syncytiotrophoblast Cells

Lee NY, Lee HE, Kang YS

  • KMID: 2048333
  • Biomol Ther.
  • 2014 Jan;22(1):68-72.
When chemotherapy is administered during pregnancy, it is important to consider the fetus chemotherapy exposure, because it may lead to fetal consequences. Paclitaxel has become widely used in the metastatic...
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Urologists' Perceptions and Practice Patterns in Peyronie's Disease: A Korean Nationwide Survey Including Patient Satisfaction

Ko YH, Moon KH, Lee SW, Kim SW, Yang DY, Moon DG, Chung WS, Oh KJ, Hyun JS, Ryu JK, Park HJ, Park K

PURPOSE: A nationwide survey was conducted of Korean urologists to illustrate physicians' perceptions and real practical patterns regarding Peyronie disease (PD). MATERIALS AND METHODS: A specially designed questionnaire exploring practice characteristics...
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Catheter Ablation of Multiple Accessory Pathways in Duchenne Muscular Dystrophy

Finsterer , Stollberger C, Steger C, Gatterer E

A 23-year-old male with Duchenne muscular dystrophy (DMD) experienced self-limiting palpitations at age 19 years for the first time. Palpitations recurred not earlier than at age 23 years, and were...
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Atrial Fibrillation during General Anesthesia Induction and Paroxysmal Supraventricular Tachycardia on Emergence

Bang YS, Shin DW, Lee TK, Park CH, Gill HJ, Lee JY

A healthy 35-year-old man who was scheduled for closed reduction of nasal bone fracture developed atrial fibrillation during induction of general anesthesia after intravenous glycopyrrolate injection. During emergence of general...
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Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration

Ok SH, Bae SI, Shim HS, Sohn JT

BACKGROUND: Dexmedetomidine is a highly selective alpha2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction...
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