Int Neurourol J.  2013 Dec;17(4):162-167.

Acute Dose-Related Differential Effects of Methylphenidate on Murine Cystometric Parameters

• Choi SH
• Cho YS
• Cho ST
• Lee T
• Kim KH

Abstract

PURPOSE
Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding. Various doses of methylphenidate were investigated for their effects on cystometric parameters in conscious mice.
METHODS
Ten male C57BL/6 mice, weighing between 20 and 23 g, were used in this study. To compare the acute drug responses before and after the oral medication was administered in the awake condition, we injected the solution through a catheter inserted into the stomach. Methylphenidate (1.25, 2.5, and 5 mg/kg) in an injection volume of 0.05 mL was administered.
RESULTS
Four mice that received high doses of methylphenidate (2.5 and 5 mg/kg) showed no voiding contraction, with urine leakage. Six mice that received a low dose of methylphenidate (1.25 mg/kg) showed typical micturition cycles before and after administration. The micturition pressure decreased and bladder capacity increased without an increased residual volume after administration.
CONCLUSIONS
Methylphenidate has differential, dose-dependent effects on the function of the lower urinary tract, due to the dependent relationship between the brain and lower urinary tract. Especially at higher doses, this drug may interfere with normal micturition. Therefore, more detailed clinical or experimental studies are warranted in the future.

Keyword

Methylphenidate; Attention deficit disorder with hyperactivity; Urodynamics; Mice; Neurogenic urinary bladder

MeSH Terms

Animals
Attention Deficit Disorder with Hyperactivity
Brain
Catheters
Central Nervous System
Humans
Male
Methylphenidate*
Mice
Residual Volume
Stomach
Urinary Bladder
Urinary Bladder, Neurogenic
Urinary Tract
Urination
Urodynamics
Methylphenidate