Korean Circ J.  2008 Mar;38(3):152-160. 10.4070/kcj.2008.38.3.152.

Relationship Between Serum Uric Acid Level and Metabolic Syndrome According to Gender

• Hong SP
• Lee YS
• Bae KR
• Chung JW
• Kim SY
• Lee JB
• Ryu JK
• Choi JY
• Kim KS
• Chang SG
• Shin IH

• KMID: 2225832
• DOI: http://doi.org/10.4070/kcj.2008.38.3.152

Abstract

BACKGROUND AND OBJECTIVES
Hyperuricemia is known to be a risk factor for atherosclerosis, as is gender. The variables related to metabolic syndrome (MS), as well as other cardiovascular risk factors such as serum uric acid (SUA), differ according to gender. The aim of this study was to evaluate the relationship between SUA and the variables of MS according to gender.
SUBJECTS AND METHODS
We randomly recruited 675 subjects (373 men and 302 women), who underwent health screening. The subjects were divided into four groups according to SUA quartiles. We compared each quartile of the SUA with the incidence of MS. The variables included body mass index (BMI), hypertension, fasting blood glucose (FBS), high-density lipoprotein (HDL) cholesterol, triglyceride (TG), and the MS score.
RESULTS
The incidence of MS in men was significantly increased compared to women, and the incidence of MS was increased according to the SUA values in women. The MS scores tended to increase according to the SUA values in both genders. The incidence of high BMI, high blood pressure, and high TG were correlated with the SUA values in both genders. However, HDL-cholesterol was correlated with MS scores in women, and fasting glucose was not correlated with MS in either gender.
CONCLUSION
The variables of the MS might be independently associated with SUA values in both genders. In addition, the incidence of MS in women might be significantly increased according to the SUA values. However, large scale follow-up studies will be required to confirm these possibilities.

Keyword

Uric acid; Metabolic syndrome; Gender

MeSH Terms

Atherosclerosis
Blood Glucose
Body Mass Index
Cholesterol
Fasting
Female
Glucose
Humans
Hypertension
Hyperuricemia
Incidence
Lipoproteins
Male
Mass Screening
Risk Factors
Uric Acid
Blood Glucose
Cholesterol
Glucose
Lipoproteins
Uric Acid

Figure

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  Fig. 1 Relationship between obesity and serum uric acid (SUA) quartiles.

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  Fig. 2 Relationship between increased blood pressure and serum uric acid (SUA) quartiles.

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  Fig. 3 Relationship between high triglyceride and serum uric acid (SUA) quartiles.

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  Fig. 4 Relationship between low high-density lipoprotein (HDL) cholesterol and serum uric acid (SUA) quartiles.

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  Fig. 5 Relationship between fasting hyperglycemia and serum uric acid (SUA) quartiles.

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  Fig. 6 Relationship between score of metabolic syndrome and serum uric acid (SUA) quartiles.

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  Fig. 7 Relationship between metabolic syndrome and serum uric acid (SUA) quartiles.

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  Fig. 8 Relationship between metabolic syndrome and serum uric acid (SUA) quartiles according to menopause.

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