J Korean Ophthalmol Soc.  2013 Apr;54(4):610-617. 10.3341/jkos.2013.54.4.610.

Predictive Factors for Visual Outcome after Treatment for Myopic Choroidal Neovascularization

Affiliations
  • 1Department of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. ihyun@inje.ac.kr
  • 2Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Abstract

PURPOSE
To determine predictive factors associated with visual outcome after treatment for myopic choroidal neovascularization (mCNV).
METHODS
Medical records of the patients who underwent photodynamic therapy (PDT), intravitreal anti-vascular endothelial growth factor (Anti-VEGF) injection, or combination therapy of PDT and Anti-VEGF for myopic CNV, and followed up for more than a year, were reviewed retrospectively. Multiple linear regression analyses were performed to evaluate the predictive factors significantly associated with the visual outcome at 1 year after the treatment.
RESULTS
Mean best-corrected visual acuity (BCVA) of 45 eyes of 45 patients showed statistically significant improvement 1 year after the treatment with a mean of 3.5 line improvement (p < 0.01, Wilcoxon signed rank test). Age, 1-month BCVA after treatment and treatment type appeared to be associated with the 1-year visual outcome after treatment for mCNV (p = 0.033, p < 0.001, and p = 0.044, respectively, multivariate linear regression analysis).
CONCLUSIONS
Younger age (less than 40 years), better 1-month BCVA after treatment, intravitreal Anti-VEGF monotherapy were associated with improved visual outcome after treatment for mCNV. In particular, 1-month BCVA after treatment is a useful indicator to predict therapeutic response after treatment for mCNV.

Keyword

Anti-VEGF; Bevacizumab; Myopic CNV; PDT; Ranibizumab

MeSH Terms

Antibodies, Monoclonal, Humanized
Choroid
Choroidal Neovascularization
Endothelial Growth Factors
Eye
Humans
Linear Models
Medical Records
Photochemotherapy
Retrospective Studies
Triazenes
Visual Acuity
Bevacizumab
Ranibizumab
Antibodies, Monoclonal, Humanized
Endothelial Growth Factors
Triazenes

Figure

  • Figure 1. Mean best corrected visual acuity (log MAR) changes of all eyes after the first treatment. M ean best-corrected visual acuity (BCVA) of forty five eyes of 45 patients showed statistically significant improvement at each time points after the treatment (p < 0.01, Wilcoxon signed rank test).

  • Figure 2. Mean best corrected visual acuity (BCVA, log MAR) changes at 1 year after the first treatment of the groups. M ean BCVA of all groups improved significantly at 1 year after the treatment (p = 0.028, p < 0.01, p = 0.037, respectively, in group A, B and C, W ilcoxon signed rank test).


Reference

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