J Korean Surg Soc.  2010 Nov;79(5):369-376. 10.4174/jkss.2010.79.5.369.

Bacteriologic Study and Antibiotics Sensitivity of Acute Appendicitis Treated with Laparoscopic Appendectomy

• Lee JW
• Park JM
• Lee SE
• Park YG
• Chi KC

• KMID: 2212044
• DOI: http://doi.org/10.4174/jkss.2010.79.5.369

Abstract

PURPOSE
This study was designed to evaluate the bacteriological characteristics and antibiotics sensitivity in acute appendicitis.
METHODS
The microbiologic culture and antibiotics sensitivity tests were done on 165 patients who underwent laparoscopic appendectomy under the diagnosis of acute appendicitis. The postoperative complications were also checked. The microbiologic and clinical results were compared between perforated and non-perforated groups.
RESULTS
The most common organism cultured from the periappendiceal fluid was Escherichia coli (51.2%), followed by Enterobacter (16.2%) and Pseudomonas (8.9%). In the antibiotics sensitivity test, ciprofloxacin and levofloxacin were highly susceptible. Ceftriaxone and cefotaxime were also highly susceptible. Piperacillin/tazobactam, imipenem and meropenem were very highly susceptible. The complication rate of perforated appendicitis group (17.9%) was higher than that of the non-perforated appendicitis group (7.1%) (P<0.001). A surgical drain was used more frequently in perforated group (23% vs 84.6%, P<0.001). The mean in-patient days were longer in the perforated group (5.7 vs 7.2 days, P<0.001). In the patients with infectious wound complication, antibiotic resistance was more prominent in the non-perforated group than in the perforated group.
CONCLUSION
In the perforated appendicitis group, more precise and careful procedure was required. In the non-perforated appendicitis group, more prudent use of the available antibiotics to conserve valuable therapeutic resources and improved infection control to limit the spread of resistant organisms was required.

Keyword

Appendicitis; Laparoscopic appendectomy; Microbiology; Antibiotics susceptibility test

MeSH Terms

Anti-Bacterial Agents
Appendectomy
Appendicitis
Cefotaxime
Ceftriaxone
Ciprofloxacin
Drug Resistance, Microbial
Enterobacter
Escherichia coli
Humans
Imipenem
Infection Control
Ofloxacin
Postoperative Complications
Pseudomonas
Thienamycins
Anti-Bacterial Agents
Cefotaxime
Ceftriaxone
Ciprofloxacin
Imipenem
Ofloxacin
Thienamycins

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