J Korean Rheum Assoc.  2010 Mar;17(1):76-80. 10.4078/jkra.2010.17.1.76.

A Case of Dermatomyositis Associated with Infiltrative Intrahepatic Cholangiocarcinoma

• Choi SH
• Kim HS
• You MR
• Kim MW

• KMID: 2201997
• DOI: http://doi.org/10.4078/jkra.2010.17.1.76

Abstract

Dermatomyositis is a distinctive entity that is identified by a characteristic rash that accompanies or more often precedes proximal muscle weakness. There is a well recognized association between dermatomyositis and several cancers, such as ovarian cancer, lung cancer, pancreas cancer, stomach cancer and colorectal cancers and non-Hodgkin Lymphoma. But dermatomyositis associated with intrahepatic cholangiocarcinoma has not yet been reported in Korea. We experienced a case of dermatomyositis associated with infiltrative intrahepatic cholangiocarcinoma and we report on this unusual case along with reviewing the related literature.

Keyword

Dermatomyositis; Intrahepatic cholangiocarcinoma; Malignancy

MeSH Terms

Cholangiocarcinoma
Colorectal Neoplasms
Dermatomyositis
Exanthema
Korea
Liver Neoplasms
Lung Neoplasms
Lymphoma, Non-Hodgkin
Muscle Weakness
Ovarian Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Cholangiocarcinoma
Liver Neoplasms

Figure

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  Fig. 1. The patients shows violaceous erythema on the forehead and the bilateral cheeks involving the nasolabial fold.

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  Fig. 2. The histology of the skeletal muscle from the gluteus medius muscle shows perivascular lymphocyte infiltration and inflammatory cell infiltrates into the perimuscular area (long arrow), and perifascicular atrophy (short arrow). These findings are suggestive of inflammatory myopathy (H&E stain, ×200)

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  Fig. 3. A poorly defined and less enhanced lesion is noted in the right lobe of the liver with one dilated bile duct (A). A small metastatic nodule is seen in the lower lobe of the right lung (B). There is no involvement within the hilum and note the right portal vein thrombus (C).

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