J Korean Soc Transplant.  2007 Jun;21(1):69-74.

Renal Biopsy Findings of Prospective Kidney Donors and Clinical Course of Renal Allografts

• Yoon HE
• Kim SH
• Kim YK
• Roh ES
• Chun YJ
• Lee HY
• Yu JH
• Moon IS
• Yang CW
• Kim YS
• Bang BK

Abstract

PURPOSE: To evaluate the pathology of prospective kidney donors and assess the clinical outcomes of the renal allografts.
METHODS
We reviewed the records of 12 prospective kidney donors who underwent kidney biopsy. The indications of kidney biopsy were asymptomatic microscopic hematuria (n=88, 66.7%), decreased glomerular filtration rate (GFR, n=22, 16.7%), mild proteinuria (n=11, 8.3%), history of gross hematuria (n=11, 8.3%).
RESULTS
Kidney biopsy in 8 prospective donors with asymptomatic microscopic hematuria showed: 5 (62.5%) thin basement membrane disease (TBMD); 1 IgA nephropathy; 1 Alport's syndrome; 1 mild mesangial widening. Two prospective donors with decreased GFR showed IgA nephropathy and tubulointerstitial lesion. The one with mild proteinuria showed arterionephrosclerosis and the one with a history of gross hematuria showed tubulointerstitial lesion. 4 (33.3%) of the 12 who underwent kidney biopsy were accepted as kidney donors.; 3 donors with TBMD and the donor with mild mesangial widening, who all had microscopic hematuria. Among the 4 donations, there was 1 graft failure and 3 allografts (1 mild mesangial widening, 2 TBMD) have maintained graft function at latest follow up.
CONCLUSION
The most common cause of asymptomatic microscopic hematuria in prospective kidney donors was TBMD. Long-term follow up is needed to assess the clinical outcomes of these allografts.

Keyword

Kidney donor; Kidney biopsy; Asymptomatic hematuria; Proteinruia

MeSH Terms

Allografts*
Basement Membrane
Biopsy*
Follow-Up Studies
Glomerular Filtration Rate
Glomerulonephritis, IGA
Hematuria
Humans
Kidney*
Nephritis, Hereditary
Pathology
Prospective Studies*
Proteinuria
Tissue Donors*
Transplants