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Case 12: A 84-Year-Old Man With Decreased Consciousness and Hyperpnea

Lee SH, Shin C, Hwang I, Kim H, Kim Y, Park HS, Park CW, Yang CW, Chung BH, Ko EJ, i Lee H

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CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats

Jin L, Shen N, Wen X, Wang W, Lim SW, Yang CW

Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced...
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The comparative efficacy and safety of basiliximab and antithymocyte globulin in deceased donor kidney transplantation: a multicenter cohort study

Hong SY, Kim YS, Jin K, Han S, Yang CW, Chung BH, Park WY

Background: Generally, an induction agent is chosen based on the conditions of the deceased donor and the recipient. Antithymocyte globulin (ATG) is preferred in relatively high-risk conditions. No clear evidence...
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Newly diagnosed metastatic pulmonary calcification in a kidney transplantation recipient: a case report

Youn S, Yang CW, Chung BH, Ko EJ

Metastatic pulmonary calcification (MPC) is defined as calcium deposition in lung tissues. It is commonly seen in end-stage renal disease patients. However, MPC occurring in kidney transplant recipients (KTRs) is...
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Severity of post-COVID-19 organizing pneumonia in kidney transplant recipients according to SARS-CoV-2 vaccination

Choi S, Lee H, Kim HD, Ko EJ, Yang CW, Chung BH

Kidney transplant recipients (KTR) are on maintenance immunosuppression, therefore showed a higher risk for infection including coronavirus disease 2019 (COVID-19). In addition, the risk of progression to severe state of...
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Recurrent atypical hemolytic uremic syndrome after kidney transplantation: a case report

Park H, Park HW, Lee H, Yang CW, Chung BH

The etiology of end-stage kidney disease (ESKD) is uncertain in some patients. Atypical hemolytic uremic syndrome (aHUS) is a rare disease that could cause kidney damage. We herein present a...
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Long-term clinical outcomes of ABO incompatible kidney transplantation in patients with high baseline anti-A/B antibody titer

Eum SH, Lee H, Ko EJ, Yoon HE, Shin SJ, Yang CW, Chung BH

Background: ABO incompatible (ABOi) kidney transplantation (KT) has been considered to overcome donor shortage. We investigated the long-term clinical outcomes in ABOi KT in patients with high baseline anti-A/B antibody...
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Clinical relevance and characteristics of pretransplant donor-specific anti-human leukocyte antigen-DQ antibodies in kidney transplantation

Lee H, Eum SH, Ko EJ, Oh EJ, Yang CW, Chung BH

Background: Pretransplant detection of donor-specific anti-human leukocyte antigen antibody (HLA-DSA) is associated with adverse allograft outcomes such as posttransplant development of antibody mediated rejection (ABMR). However, the impact of HLA-DSA...
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Prospective study to evaluate the effectiveness of donor-derived cell-free DNA for early diagnosis of biopsy-proven rejection in renal transplant recipients

Kim HD, Bae H, Eum SH, Lee H, Ko EJ, Yang CW, Chung BH, Oh EJ

Background: In this study, we investigated to verify whether the titer of donor-derived cell-free DNA (dd-cfDNA) has diagnostic value in predicting biopsy-proven rejection in kidney transplant recipients (KTR). Methods: This study...
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Discovery of cellular and molecular pathways involved in the development of anti-human leukocyte antigen antibody through single cell RNA sequencing in highly sensitized mouse model

Lee H, Eum SH, Yang CW, Chung BH

Background: Presence of allo-antibody to human leukocyte antigen (HLA), so called sensitization is an important obstacle for successful kidney transplantation. It is well known that B-cell lineage including antibody producing...
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Acute kidney injury in kidney transplant recipients with active SARS-CoV-2 infection due to drug interaction of tacrolimus and nirmatrelvir/ritonavir: three serial case reports

Park H, Ko EJ, Chung BH, Yang CW

The mortality of SARS-CoV-2 infection of kidney transplant recipients (KTR) is higher than that of general population since immu-nocompromised condition. A novel oral protease inhibitor against SARS-CoV-2, nirmatrelvir (NR) is...
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Impact of low-level donor-specific anti-HLA antibody on posttransplant clinical outcomes of kidney transplant recipients: analysis from Korean Organ Transplantation Registry data

Lee H, Park JH, Park JW, Ban TH, Yang J, Kim MS, Yang CW, Chung BH, Korean Organ Transplantation Registry

Background: The clinical relevance of donor-specific anti-human leukocyte antigen antibody (HLA-DSA), detected only by solid phase assay (SPA) remains controversial. This study aimed to investigate the impact of low-level donor-specific...
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Combined impact of tacrolimus interpatient variability and intrapatient variability on allograft outcomes in kidney transplantation

Park Y, Lee H, Eum SH, Yoon SH, Hwang WM, Yun SR, Yang CW, Shin J, Chung BH

Background: Concentration to dose ratio (CDR) of tacrolimus (TAC) is an index of inter-patient variability that reflects TAC me-tabolism, and whether it influences allograft outcomes is controversial in kidney transplantation...
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Successful Living Donor Kidney Transplantation in a Patient with MTHFR Deficiency and Heparin-Induced Thrombocytopenia: A Case Report

Kang D, Lee H, Chung BH, Choi BS, Yang CW, Ko EJ

Perioperative anticoagulation in a kidney transplant recipient with heparin-induced thrombocytopenia is challenging due to paradoxical hypercoagulability. A 49-year-old man with end-stage kidney disease and a previous stroke history was referred...
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Ureteral stent infection caused by Candida in a renal transplant recipient

Lee H, Chung BH, Yang CW, Sun IO

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COVID-19–related clinical outcomes among Korean hemodialysis patients

Park HC, Lee YK, Ko E, Yu S, Cho A, Kim DH, Kim J, Cho JH, Lee J, Kim DK, Kim SN, Yang CW, on behalf of the Korean Society of Nephrology COVID-19 Task Force Team

Background: Hemodialysis (HD) patients are more vulnerable to viral epidemics, experiencing higher mortality rates compared to individuals without chronic kidney disease (CKD). This retrospective cohort study sought to demonstrate clinical...
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Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model

Lim SW, Shin YJ, Cui S, Ko EJ, Yoo SH, Chung BH, Yang CW

Background/Aims: We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for...
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Crohn’s Disease Identified as Granulomatous Tubulointerstitial Nephritis

Han JS, Choi BS, Park CW, Choi YJ, Yang CW, Lee HH, Ban TH

Crohn’s disease is usually diagnosed according to intestinal symptoms, but extra-intestinal manifestations are important in approximately one-third of cases. Although several extra-intestinal symptoms associated with various organs have been reported,...
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Successful ABO-incompatible kidney transplantation and SARS-CoV-2–specific immune monitoring in a patient recovered from coronavirus infection

Hong SY, Bae H, Park SC, Yang CW, Oh EJ, Chung BH

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Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells

Lim SW, Kim KW, Kim BM, Shin YJ, Luo K, Quan Y, Cui S, Ko EJ, Chung BH, Yang CW

Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced...
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