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Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin

Espósito , Brianezi G, de Souza N, Miot LD, Miot HA

BACKGROUND: Melasma is a chronic acquired focal hypermelanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known about...
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Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma

Hur GY, Broide DH

Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized...
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De novo mutations in COL4A5 identified by whole exome sequencing in 2 girls with Alport syndrome in Korea

Han KH, Park JE, Ki CS

Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (α3, α4, and α5). ATS is characterized by persistent microscopic...
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Clinical Analysis of Findings for Anterior Segment Optical Coherent Tomography in Recurrent Corneal Erosion Syndrome

Kim YM, Eom HD, Yoon DH, Kim HK

PURPOSE: To evaluate the correlation between abnormal findings seen in anterior segment optical coherent tomography and the recurrence rate in patients with recurrent corneal erosion syndrome. METHODS: Between January 2015 and...
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Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy

Suh KS, Choi SY, Bae GE, Choi DE, Yeo MK

Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune...
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Pathology of C3 Glomerulopathy

Shin SJ, Seong Y, Lim BJ

C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed...
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Genetic Basis of Steroid Resistant Nephrotic Syndrome

Park E

Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease. Identifying a monogenic cause for...
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Basement Membrane Status Is Intact in Urticarial Dermatitis vs. Adult-Onset Atopic Dermatitis

Kim TI, Park HJ, Won YY, Choi H, Jeong KH, Sung JY, Shin MK

No abstract available.
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Ameliorative effect of vitamin B12 on seminiferous epithelium of cimetidine-treated rats: a histopathological, immunohistochemical and ultrastructural study

Elsaed WM, Bedeer RF, Eladl MA

Cimetidine is an H2 receptor antagonist that has an antiandrogenic effect. It intervenes with the conversion of testosterone into estrogen in the Sertoli cells with accompanying testicular structural changes. In...
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The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate

Chae JB, Choi HR, Shin JW, Na JI, Huh CH, Park KC

BACKGROUND: Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a flavonoid known to have a wide range of pharmacological activities. The 3-OH group in flavonoids has been reported to determine antioxidant activities. OBJECTIVE: We tested whether...
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Piperacillin-Tazobactam-Induced Linear IgA Bullous Dermatosis Supported by a T-Cell Activation Assay

Ho YH, Chiu YW, Liu HN

Linear immunoglobulin (Ig) A bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease characterized by linear IgA deposits at the basement membrane zone visualized with direct immunofluorescence (DIF). Most...
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Unusual Case of Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis: A Case Report and Review of the Literature

Cha B, Kim DY, Jang H, Hwang SD, Choi HJ, Kim MJ

Posterior reversible encephalopathy syndrome (PRES) is characterized by a clinical and radiological entity with the sudden onset of seizures, headache, altered consciousness, and visual disturbances in patients with the findings...
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Systemic Lupus Erythematosus Presenting as Stevens-Johnson Syndrome: A Case Report

Lee KG, Koh BY, Kwon ES, Myung KB, Kwon MH, Cheong SH

  • KMID: 2386240
  • Korean J Dermatol.
  • 2017 Jun;55(5):293-296.
Acute cutaneous lupus erythematosus (ACLE) on the face is a usual pattern of presentation. However, it can rarely present with a generalized distribution. A hyperacute form of ACLE can mimic...
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Recent Research Trend for Ménière's Disease

Nam SI

Ménière's disease is a poorly understood disorder of the inner ear characterized by intermittent episodic vertigo, fluctuating hearing loss, ear fullness and tinnitus. In this paper, we present a review...
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Transcriptional regulatory networks underlying the reprogramming of spermatogonial stem cells to multipotent stem cells

Jeong HS, Bhin J, Kim HJ, Hwang D, Lee DR, Kim KS

Spermatogonial stem cells (SSCs) are germline stem cells located along the basement membrane of seminiferous tubules in testes. Recently, SSCs were shown to be reprogrammed into multipotent SSCs (mSSCs). However,...
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Long-term Prognosis of thin Glomerular Basement Membrane Nephropathy in Children: A Retrospective Single Center Study

Lim MH, Bae HJ, Jang KM, Park YH

PURPOSE: Thin glomerular basement membrane nephropathy (TBMN) is, along with the IgA nephropathy, the most common cause of asymptomatic hematuria in Korean children. TBMN is usually a benign renal disease...
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A case of generalized argyria presenting with muscle weakness

Jung I, Joo EJ, Suh BS, Ham CB, Han JM, Kim YG, Yeom JS, Choi JY, Park JH

BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble...
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Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice

Jung GS, Jeon JH, Choe MS, Kim SW, Lee IK, Kim MK, Park KG

BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used in the treatment of patients with type 2 diabetes and have proven protective effects on diabetic kidney disease (DKD). Whether DPP-4 inhibitors...
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Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells into the Testes of Infertile Male Rats and New Germ Cell Formation

Ghasemzadeh-Hasankolaei M, Batavani R, Eslaminejad MB, Sayahpour

BACKGROUND: Mesenchymal stem cells (MSCs), have been suggested as a potential choice for treatment of male infertility. Yet, the effects of MSCs on regeneration of germinal epithelium of seminiferous tubules...
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Clinical Manifestations of Extruded Conjunctival Melanocytic Mass

Jang SG, Park BG, Park YM, Lee JS

PURPOSE: To investigate the clinical manifestations and characteristics of extruded conjunctival melanocytic mass. METHODS: A total of 33 patients who had extruded conjunctival melanocytic mass and who underwent excisional biopsy were...
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