Korean J Med.
2016 Jun;90(6):545-549. 10.3904/kjm.2016.90.6.545.
De Novo AL Amyloidosis in a Renal Allograft
- Affiliations
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- 1Department of Internal Medicine, Maryknoll Hospital, Busan, Korea. egis70@naver.com
- 2Division of Nephrology, Department of Internal Medicine, Maryknoll Hospital, Busan, Korea.
- KMID: 2218780
- DOI: http://doi.org/10.3904/kjm.2016.90.6.545
Abstract
- Amyloidosis is characterized by the extracellular deposition of amyloid in various tissues and organs, particularly the kidney and heart. The estimated incidence of systemic amyloidosis is at least 8 per million population per year. However, few cases of systemic amyloidosis in renal allografts have been reported. A stable renal transplant recipient was admitted with proteinuria and dyspnea on exertion. The M-peak was found on serum and urine protein electrophoresis, and lambda (λ) dominance was confirmed by serum and urine free-light-chain test. The patient was diagnosed with systemic amyloidosis of a renal allograft, by allograft biopsy, at 22 years after renal transplantation. We report a case of AL amyloidosis in a stable renal allograft and review the medical literature.
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