J Korean Orthop Assoc.  2007 Jun;42(3):305-309. 10.4055/jkoa.2007.42.3.305.

Smoking, Alcohol Intake and the Risk of Dupuytren's Disease in Koreans

• Hahn SB
• Kang HJ
• Lee SH
• Kim HK

• KMID: 2186553
• DOI: http://doi.org/10.4055/jkoa.2007.42.3.305

Abstract

PURPOSE: This study evaluated the relationship between Dupuytrens disease and smoking and alcohol intake.
MATERIALS AND METHODS
Forty eight patients with Dupuytrens disease, who underwent a partial fasiectomy were examined retrospectively through a chart review and a telephone interview. The minimum follow-up period was 12 months. The relationship between Dupuytren's disease and smoking and alcohol intake were analyzed using multivariate logistic regression with significance set at p<0.05.
RESULTS
Dupuytren's disease requiring surgery in these patients was associated with heavy alcohol intake (odds ratio 2.91) and alcohol intake per week (odds ratio 1.22). The average smoking level was 24.7 pack-year for cases compared with 16.1 pack-year for controls (p<0.05). The average alcohol intake was 3.0 units per week for the cases compared with 1.2 units per week for controls (p<0.05). Smoking was not an independent risk factor but increased the risk when combined with heavy alcohol intake.
CONCLUSION
Heavy alcohol intake is an independent risk factor of Dupuytren's disease in Korean. Smoking is not an independent risk factor but increases the risk when combined with heavy alcohol intake.

Keyword

Dupuytren; Smoking; Alcohol

MeSH Terms

Dupuytren Contracture*
Follow-Up Studies
Humans
Interviews as Topic
Logistic Models
Retrospective Studies
Risk Factors
Smoke*
Smoking*
Smoke

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