J Korean Acad Rehabil Med.
2006 Oct;30(5):447-454.
Chronological Changes in Cerebral Infarction of Photochemical Thrombosis Model: Magnetic Resonance Imaging and Histopathological Correlation
- Affiliations
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- 1Department of Neurosurgery, Wonkwang University Medical School, Korea.
- 2Department of Rehabilitation Medicine, Wonkwang University Medical School, Korea. cbrmshin@wonkwang.ac.kr
- 3Department of Pharmacology, Wonkwang University Medical School, Korea.
- 4Department of Institute for Radiological Imaging Science, Wonkwang University Medical School, Korea.
- 5Department of Neurosurgery, Presbyterian Medical Center, Korea.
- 6Department of Pathology, Chonnam National University School of Medicine, Korea.
- 7Department of Radiology, Chonbuk National University School of Medicine, Korea.
Abstract
OBJECTIVE
Authors investigated magnetic resonance imaging (MRI) and histological characteristics of photothrombotic infraction rat model (PIRM) on long term basis to provide a basis for further research. METHOD: Photothrombotic ischemia was induced in male Sprague-Dawley rats using Rose-bengal dye (20 mg/kg) and cold light. MRI was performed 1, 6, 12, 24 hours, 3, 7 days, 2, 3, 4, 6, and 8 weeks after photothrombosis and obtained T1- & T2-weighted and contrast-enhanced images. Also, T2* images were obtained after superparamagnetic iron oxide injection. After MRI, animals were sacrificed and the brain sections were stained for routine immunohistopathology.
RESULTS
MRI and histological analysis revealed well induced lesion in the cortex and showed biological course of infarction. However, PIRM showed rapid development of infarction lacking collateral circulation. Infarction size reached maximum 12 hours after induction, progressively decreasing over 4 weeks. Interstitial and cytotoxic edema were evident at 6, 12, 24 hours, but decreasing afterwards. Neurogenic inflammation appeared on 3rd day and reached maximum on 5~7th day. Arachnoid membrane was characteristically invaded with inflammatory cells and later thickened with fibrosis.
CONCLUSION
This study showed PIRM is ideal model to study subacute and chronic stages of cerebral infarction.
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