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Effects of Mesenchymal Stem Cells Treatment on Radiation-Induced Proctitis in Rats

Kim WH, Yoo JH, Yoo IK, Kwon CI, Hong SP

Purpose: There are no effective treatment methods with which to control complications of radiation proctitis with fistula or recurrent bleeding following radiation treatment for prostate, cervical, or rectal cancer. Mesenchymal...
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Establishment of a novel experimental model of infected anal fistula in rat

Zhao M, Wang A, Zhang L, Yu H

Refractory Crohn’s-like enterocutaneous fistula indicates the aggressive manifestation and lead to poor prognosis of patients. The development of multidisciplinary strategies for fistula administration largely subjects to the deficiency of animal...
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Assessment of Bacterial Communities Within the Biofilm of Bladder Calculi in the Neurogenic Bladder Rat Model Following Spinal Cord Injury

Lee JW, Lee SS, Yang SH, Choe HS

Purpose: To develop a rat model of bladder calculi in the neurogenic bladder following spinal cord injury (SCI) and assess bacterial communities within the biofilm of bladder calculi using denaturing...
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Polydeoxyribonucleotide and Polynucleotide Improve Tendon Healing and Decrease Fatty Degeneration in a Rat Cuff Repair Model

Hwang JT, Lee SS, Han SH, Sherchan B, Panakkal JJ

BACKGROUND: After surgical repair of chronic rotator cuff tears, healing of the repaired tendons often fails and is accompanied by high-level fatty degeneration. Our purpose was to explore the effects...
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The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion

Hwang S, Chung CJ, Choi YJ, Kim T, Kim KH

OBJECTIVE: The objective of this study was to evaluate the effects of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion. METHODS: Sixty male Sprague–Dawley rats were...
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Bladder Augmentation Using Lyoplant® : First Experimental Results in Rats

Winde F, Backhaus K, Zeitler JA, Schlegel N, Meyer T

BACKGROUND: Congenital defects of the urinary bladder (micro- or contracted bladder, bladder exstrophy) remain a challenging problem for pediatric surgeons. Even when conservative treatment options are fully exhausted, irreversible renal...
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Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment

Ahn M, Kim J, Park C, Cho J, Jee Y, Jung K, Moon C, Shin T

Glycogen synthase kinase (GSK)-3β has been known as a pro-inflammatory molecule in neuroinflammation. The involvement of GSK-3β remains unsolved in acute monophasic rat experimental autoimmune encephalomyelitis (EAE). The aim of...
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Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Li D, Yan Y, Yu L, Duan Y

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its...
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Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model

Orasan MS, Bolfa P, Coneac A, Muresan A, Mihu C

BACKGROUND: Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE: This study investigated the efficacy of three chemical treatments used in humans for hair loss, using...
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Development of animal model for Bisphosphonates-related osteonecrosis of the jaw (BRONJ)

Jang HW, Kim JW, Cha IH

BACKGROUND: The aim of this study is to develop a rat model of bisphosphonates-related osteonecrosis of the jaw (BRONJ) that would be verified with clinical, radiological and histological examination, and...
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Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation

Fukuda T, Yamashita , Hisano S, Tanaka M

BACKGROUND: Neuropathic pain is a global clinical problem; nevertheless, nerve injury treatment methods remain limited. Olanzapine has antinociceptive and anti-nueropathic properties; however, its preventive effects have not been assessed in...
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Enhanced Efficacy of Human Brain-Derived Neural Stem Cells by Transplantation of Cell Aggregates in a Rat Model of Parkinson's Disease

Shin ES, Hwang O, Hwang YS, Suh JK, Chun YI, Jeon SR

OBJECTIVE: Neural tissue transplantation has been a promising strategy for the treatment of Parkinson's disease (PD). However, transplantation has the disadvantages of low-cell survival and/or development of dyskinesia. Transplantation of...
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Chlorogenic Acid Decreases Retinal Vascular Hyperpermeability in Diabetic Rat Model

Shin JY, Sohn J, Park KH

To evaluate the effect of chlorogenic acid (CGA), a polyphenol abundant in coffee, on retinal vascular leakage in the rat model of diabetic retinopathy, Sprague-Dawley rats were divided into four...
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Therapeutic potentials occurring during the early differentiation process of mesenchymal stem cells in a rats model with thioacetamide-induced liver fibrosis

Choi ST, Hwang S, Hong HN, Won YJ, Ahn CS, Ha TY, Song GW, Jung DH, Park GC, Lee SG

BACKGROUNDS/AIMS: Mesenchymal stem cells (MSCs) have the capacity to differentiate into hepatocytes, The purpose of this study is to investigate the MSCs' differentiation process and therapeutic potentials by comparing isolated...
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The Effect of Hyaluronate-Carboxymethyl Cellulose on Bone Graft Substitute Healing in a Rat Spinal Fusion Model

Lee JH, Jeong BO

OBJECTIVE: The aim of this study was to evaluate the impact of sodium hyaluronate-sodium carboxymethyl cellulose (HA-CMC), an anti-adhesive material for spinal surgery, on bone fusion by applying it to...
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Survival, Exercise Capacity, and Left Ventricular Remodeling in a Rat Model of Chronic Mitral Regurgitation: Serial Echocardiography and Pressure-Volume Analysis

Kim KH, Kim YJ, Lee SP, Kim HK, Seo JW, Sohn DW, Oh BH, Park YB

BACKGROUND AND OBJECTIVES: The aims of this study were to establish a reliable model of chronic mitral regurgitation (MR) in rats and verify the pathophysiological features of this model by...
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Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

Lee YS, Kwon ST, Kim JO, Choi ES

OBJECTIVE: We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic...
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Effects of Electrical Stimulation and Weight-Supported Treadmill Gait Simulation on Apoptosis in the Muscles of Rats with Spinal Cord Injury

Kim JH, Bang MS

  • KMID: 2326490
  • J Korean Acad Rehabil Med.
  • 2010 Dec;34(6):613-621.
OBJECTIVE: To assess the effect of electrical stimulation and weight-supported treadmill gait simulation on apoptosis in the muscles of rats with spinal cord injury. METHOD: Twenty seven rats with a model...
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Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats

Park ES, Jeon Y, Cho DC, Youn DH, Gwak YS

  • KMID: 2312071
  • Lab Anim Res.
  • 2010 Sep;26(3):225-232.
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as...
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The Changes of the Erectile Function and Histology of the Corpus Cavernosum in a Rat Model of Metabolic Syndrome

Kim SD, Cho SY, Sohn DW, Lee DS, Jeong MS, Kim DB, Kim HS, Cho YH, Park CW, Kim SW

  • KMID: 2226548
  • Korean J Androl.
  • 2008 Dec;26(4):187-196.
PURPOSE: We evaluated the changes of the erectile function and histology of the corpus cavernosum in a rat model of metabolic syndrome. MATERIALS AND METHODS: We used male spontaneous hypertensive rats...
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