Diabetes Metab J.  2013 Jun;37(3):207-211. 10.4093/dmj.2013.37.3.207.

Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy

  • 1Department of Endocrinology, Gwangmyeong Sung Ae Hospital, Gwangmyeong, Korea.
  • 2Department of Endocrinology, Good Morning Hospital, Pyeongtaek, Korea.
  • 3Division of Endocrinology, Institute of Endocrine Research, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ejlee423@yuhs.ac
  • 4Department of Endocrinology and Metabolism, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 5Department of Endocrinology and Metabolism, National Health Insurance Cooperation Ilsan Hospital, Goyang, Korea.
  • 6Dr.Cho's Internal Medicine Clinic, Seoul, Korea.
  • 7Department of Endocrinology and Metabolism, CHA Bundang Medical Center, CHA University, Seongnam, Korea. spark@cha.ac.kr


Beyond statin therapy for reducing low density lipoprotein cholesterol (LDL-C), additional therapeutic strategies are required to achieve more optimal reduction in cardiovascular risk among diabetic patients with dyslipidemia. To evaluate the effects and the safety of combined treatment with omega-3 fatty acids and statin in dyslipidemic patients with type 2 diabetes, we conducted a randomized, open-label study in Korea. Patients with persistent hypertriglyceridemia (> or =200 mg/dL) while taking statin for at least 6 weeks were eligible. Fifty-one patients were randomized to receive either omega-3 fatty acid 4, 2 g, or no drug for 8 weeks while continuing statin therapy. After 8 weeks of treatment, the mean percentage change of low density lipoprotein (LDL) particle size and triglyceride (TG) level was greater in patients who were prescribed 4 g of omega-3 fatty acid with statin than in patients receiving statin monotherapy (2.8%+/-3.1% vs. 2.3%+/-3.6%, P=0.024; -41.0%+/-24.1% vs. -24.2%+/-31.9%, P=0.049). Coadministration of omega-3 fatty acids with statin increased LDL particle size and decreased TG level in dyslipidemic patients with type 2 diabetes. The therapy was well tolerated without significant adverse effects.


Diabetes mellitus, type 2; Dyslipidemia; Fatty acids, omega-3; Hypertriglyceridemia; Low density lipoprotein particle
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