Ewha Med J.  1999 Mar;22(1):17-21. 10.12771/emj.1999.22.1.17.

The Expression of bFGF m-RNA in the Gastric Cancer Tissues

Affiliations
  • 1Department of Surgery, College of Medicine, Ewha Womans University, Korea.

Abstract

BACKGROUND
S: The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.
METHODS
Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.
RESULTS
In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.
CONCLUSIONS
In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.

Keyword

Gastric cancer; Basic fibroblast growth factor; In situ hybridization; mRNA

MeSH Terms

Fibroblast Growth Factor 2
Fibroblasts
Humans
In Situ Hybridization
RNA, Messenger
Stomach Neoplasms*
Fibroblast Growth Factor 2
RNA, Messenger
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