Ewha Med J.
1999 Mar;22(1):17-21. 10.12771/emj.1999.22.1.17.
The Expression of bFGF m-RNA in the Gastric Cancer Tissues
- Affiliations
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- 1Department of Surgery, College of Medicine, Ewha Womans University, Korea.
- KMID: 2170972
- DOI: http://doi.org/10.12771/emj.1999.22.1.17
Abstract
- BACKGROUND
S: The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.
METHODS
Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.
RESULTS
In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.
CONCLUSIONS
In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.
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